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GENLIB: new function to simulate haplotype transmission in large complex genealogies
Mohan Rakesh1, Hélène Vézina2,3,4, Catherine Laprise4,5
1School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.
Summary:
Founder populations with deep genealogical data are well suited for investigating genetic variants contributing to diseases. Here, we present a major update of the genealogical analysis R package GENLIB, centered around a new function which can simulate the transmission of haplotypes from founders to probands along very large and complex user-specified genealogies.
Availability And Implementation:
The latest update of the GENLIB package (v1.1.9) contains the new gen.simuHaplo() function and is available on the CRAN repository and from https://github.com/R-GENLIB/GENLIB. Examples can be accessed at https://github.com/R-GENLIB/simuhaplo_functions.
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