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Association between congenital heart disease and autism spectrum disorders: A protocol for a systematic review and
Dan Ma1,2, Jing-Lan Huang3,2, Tao Xiong3,2
1Department of Rehabilitation Medicine, West China Second University Hospital, Sichuan University, Chengdu, China.
Insights
This review examines the link between congenital heart disease (CHD) types and autism spectrum disorder (ASD) in children. Findings aim to aid early ASD identification and intervention in CHD patients.
Area of Science:
- Pediatric Cardiology
- Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
Background:
- Congenital heart disease (CHD) is the most common pediatric heart defect.
- Children with CHD exhibit increased neurodevelopmental disorders and may have higher risks for social and communication impairments, similar to autism spectrum disorder (ASD).
- The specific relationship between CHD types and ASD remains unclear.
Purpose of the Study:
- To systematically review and meta-analyze the association between specific types of congenital heart disease and the risk of autism spectrum disorder.
- To elucidate the relationship between congenital heart disease and autism spectrum disorder.
Main Methods:
- Comprehensive literature search across major databases (Cochrane Library, Embase, PubMed, etc.).
- Meta-analysis using fixed or random effects models.
- Risk of bias assessment, heterogeneity testing (Q statistics, I²), and publication bias detection (funnel plots, Egger test).
Main Results:
- The study will provide insights into the association between various types of CHD and ASD.
- Further analysis will explore heterogeneity through subgroup and sensitivity analyses.
Conclusions:
- Evidence generated will support early identification and intervention strategies for ASD in children with CHD.
- Improved neurodevelopmental outcomes for children with CHD are anticipated through timely interventions.
Background:
Congenital heart disease (CHD), the most common heart defect in children, refers to congenital disease with abnormal development of the heart or large blood vessels during the fetal period. The researchers suggest that children with CHD show more obvious neurodevelopmental disorders than children with normal development, and children with CHD may have a higher risk of social interaction and communication disorders. This is similar to the characteristics of children with autism spectrum disorder (ASD). However, the association between type of CHD and ASD is not well understood. This systematic review and meta-analysis will reveal the relationship between type of CHD and ASD.
Methods:
We will search the Cochrane Library, Embase, PubMed, China National Knowledge Infrastructure, Wanfang, Chinese Scientific Journals Full text, and China Biology Medicine disc databases using relevant subject terms and free words. We will use a fixed effects model or random effects model for meta-analysis. The risk of bias will be assessed by the Newcastle-Ottawa Scale and the agency for health care research and quality. Heterogeneity will be tested by Q statistics and I² values. Publication bias will be detected by funnel plots and Egger test. Subgroup analyses and sensitivity analyses will also be used to explore and interpret the heterogeneity.
Results:
The study will afford additional insight into the investigation the association between type of CHD and ASD.
Conclusions:
The results will provide evidence for the early identification and early intervention of ASD in children with CHD, which may contribute to improving the neurodevelopmental outcome of children with CHD.
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