Management of cryptococcosis and toxic epidermal necrolysis in a dog

Generalized cryptococcosis with CNS involvement was diagnosed in a 3-year-old spayed German Shorthaired Pointer. Clinical findings included Horner's syndrome, generalized lymphadenopathy, temporal muscle atrophy, and chorioretinitis. Toxic epidermal necrolysis resulted after 19 days of treatment with 5-fluorocytosine and amphotericin B. After discontinuation of the 5-fluorocytosine and amphotericin B and treatment with cephradine and ketoconazole, the toxic epidermal necrolysis resolved. Treatment was completed without further complication by using amphotericin B and ketoconazole concurrently.