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Assessment of the relationship between monocyte to high-density lipoprotein ratio and subclavian artery stenosis
1Department of Cardiology, Sakarya University School of Medicine, Sakarya, Turkey. yusufcan@sakarya.edu.tr.
Insights
The monocyte-to-high-density lipoprotein ratio (MHR) is a potential biomarker for predicting subclavian artery stenosis (SAS). Higher MHR levels were significantly associated with increased SAS prevalence, suggesting MHR
Area of Science:
- Cardiovascular Medicine
- Inflammation Markers
- Vascular Disease
Background:
- Atherosclerosis is the primary cause of adult subclavian artery stenosis (SAS).
- The monocyte-to-high-density lipoprotein ratio (MHR) is an emerging indicator of inflammation, a key factor in atherosclerosis.
- SAS often remains asymptomatic, necessitating reliable diagnostic markers.
Purpose of the Study:
- To investigate the association between the MHR and the presence of SAS.
- To evaluate MHR as a potential predictive marker for SAS.
Main Methods:
- A case-control study involving 43 patients with SAS and 43 controls.
- Calculation of MHR using complete blood count data (absolute monocyte count / HDL cholesterol).
- Statistical analysis including MHR tertile comparison and receiver operating characteristic (ROC) curve analysis.
Main Results:
- MHR was significantly elevated in the SAS group compared to controls (p<0.001).
- SAS frequency increased across MHR tertiles, demonstrating a dose-response relationship.
- An MHR cut-off of 13.39 showed high accuracy (ROC AUC: 0.868) in predicting SAS, with 69.8% sensitivity and 95.3% specificity.
Conclusions:
- MHR is a convenient and accurate marker for predicting SAS.
- The correlation between MHR and SAS supports its utility in clinical practice for early detection.
Objective:
Assessment of the monocyte-to-high-density lipoprotein ratio (MHR) is a new tool for predicting inflammation, which plays a major role in atherosclerosis. Subclavian artery stenosis (SAS) is usually asymptomatic, and atherosclerosis is the most common cause of chronic obstruction of the subclavian artery in adults. The aim of this study was to determine the relationship between the MHR and SAS.
Patients And Methods:
Between January 2015 and January 2020, 43 patients with SAS and 43 patients without SAS were enrolled in the study. The patients' angiographic, demographic and clinic characteristics were reviewed from their medical records. Monocytes and HDL (high-density lipoprotein) cholesterols were measured through a complete blood count. The MHR was calculated as the ratio of the absolute monocyte count to the HDL cholesterol value. The resulting MHR values were divided into the following three groups: low (7.16 ± 1.59), moderate (11.08 ± 1.53) and high (21.70 ± 5.62). A p-value of less than 0.05 was considered significant.
Results:
MHR was found to be significantly higher in the SAS group compared to the control group with normal subclavian arteries (p<0.001). The frequency of SAS was found to increase with an increase in the MHR tertiles. Sensitivity and specificity values were 69.8% and 95.3%, respectively. The cut-off of the MHR value, taken as 13.39, was found to provide a significantly accurate prediction of the subclavian diagnosis (ROC area under the curve: 0.868, 95% CI: 0.789-0.947, p<0.001). After adjusting for other hematological parameters in the multivariate analysis, MHR (p=0.061) was found to be a predictor of the presence of SAS.
Conclusions:
This study showed that MHR can be a convenient marker for predicting SAS because of the correlation between MHR and SAS.
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