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Clinical Microfluidic Chip Platform for the Isolation of Versatile Circulating Tumor Cells
Published on: October 13, 2023
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Versatile Dynamic Bioactive Lubricant-Infused Surface for Effective Isolation of Circulating Tumor Cells
Mengqi Bai1, Xiaohua Tian2, Zengkai Wang1
1Institute for Advanced Materials, School of Materials Science and Engineering, Jiangsu University, Zhenjiang 212013, China.
Analytical Chemistry
|March 17, 2023
Summary
Researchers developed advanced slippery surfaces to efficiently capture rare circulating tumor cells (CTCs) from blood. This innovation improves cancer diagnosis accuracy and enables non-destructive cell release for further analysis in liquid biopsies.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Cancer Research
Background:
- Isolating circulating tumor cells (CTCs) from blood is challenging due to their rarity and interference from other blood components.
- Existing methods often suffer from reduced accuracy and non-specific binding, hindering effective biomarker capture.
Purpose of the Study:
- To develop novel dynamic bioactive lubricant-infused slippery surfaces (PDBLISs) for high-efficiency CTC capture and non-destructive release.
- To enhance the accuracy and antifouling properties of CTC isolation techniques.
Main Methods:
- Grafting specific polymer brushes onto quartz plates using UV light initiation.
- Utilizing reversible catechol-boronate chemistry for cancer cell-binding peptide immobilization.
- Developing patterned dynamic bioactive lubricant-infused surfaces (PDBLISs).
Main Results:
- PDBLISs demonstrated significantly improved capture efficiency for CTCs.
- The surfaces exhibited enhanced antifouling properties against non-specific cells and blood components.
- Successful capture of rare cancer cells from simulated patient blood samples was achieved.
Conclusions:
- The developed PDBLIS strategy offers a promising approach for efficient and accurate CTC isolation.
- This technology has potential applications in clinical diagnosis for various tumors and advancing liquid biopsy techniques.
