Related Experiment Video
Updated: Aug 6, 2025
05:46
Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
Published on: December 2, 2022
1.8K
MALIGNANT TRANSFORMATION OF A CHOROIDAL NEVUS AFTER 19 YEARS OF OBSERVATION FOLLOWED BY RAPID PROGRESSION OF THE
Hannah M Istre-Wilz1, Maura Di Nicola, James J Augsburger
1Ocular Oncology Service, Department of Ophthalmology, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Retinal Cases & Brief Reports
|March 17, 2023
Summary
A choroidal nevus transformed into melanoma over 19 years, requiring treatment adjustment due to rapid growth. This case emphasizes the importance of regular follow-up for choroidal nevi to detect malignant transformation early.
Area of Science:
- Ophthalmology
- Oncology
Background:
- Choroidal nevi are benign melanocytic tumors that require monitoring.
- Malignant transformation of choroidal nevi into melanoma is a known but infrequent event.
Purpose of the Study:
- To report a case of delayed malignant transformation of a choroidal nevus into melanoma.
- To highlight the potential for significant tumor growth between diagnosis and treatment.
Main Methods:
- A 71-year-old woman with a history of treated choroidal nevus was followed for 19 years.
- The patient presented with rapid lesion growth and signs of malignancy, leading to iodine-125 plaque brachytherapy.
Main Results:
- The choroidal nevus showed signs of malignant transformation, including increased thickness and subretinal fluid.
- The melanoma exhibited rapid expansion within one month of diagnosis, necessitating a radiation dose adjustment.
Conclusions:
- Choroidal nevus transformation into melanoma necessitates lifelong surveillance.
- While treatment is often initiated promptly, significant tumor growth can occur between diagnosis and therapy, requiring careful monitoring and potential dose adjustments.
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