Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

28.1K
Overview
28.1K
Cross-reactivity00:42

Cross-reactivity

31.4K
Overview
31.4K
Antibody Structure01:10

Antibody Structure

60.7K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
60.7K
Allergic Drug Reactions01:27

Allergic Drug Reactions

909
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
909
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

594
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
594

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correlates of cockroach nasal challenge responsiveness among sensitized urban children with asthma.

The journal of allergy and clinical immunology. Global·2026
Same author

Reclassification of GST Allergens Based on Their Cross-Reactivity in Two Divergent Cockroach Species.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2026
Same author

Human Plasma-Derived C1 Inhibitor for Short-Term Prophylaxis in Hereditary Angioedema With Normal C1 Inhibitor.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2026
Same author

New Allergens Approved by the WHO/IUIS Allergen Nomenclature Sub-Committee in 2021-2024 and Their Significance for Future Diagnostics, Regulation, and Research. An EAACI Task Force Report.

Allergy·2025
Same author

Optimizing Diagnosis and Treatment in Chronic Spontaneous and Inducible Urticaria: Advances, Gaps, and the Future of Personalized Care.

The journal of allergy and clinical immunology. In practice·2025
Same author

Insights From the First 820 Patients From the Brazilian Multicenter Registry of Hereditary Angioedema: The Key Role of Genetic Testing and Targeted Therapies.

The journal of allergy and clinical immunology. In practice·2025

Related Experiment Video

Updated: Aug 6, 2025

Removal and Replacement of Endogenous Ligands from Lipid-Bound Proteins and Allergens
09:09

Removal and Replacement of Endogenous Ligands from Lipid-Bound Proteins and Allergens

Published on: February 24, 2021

3.0K

Cockroach allergy: Understanding complex immune responses to develop novel therapies.

Anna Pomés1, L Karla Arruda2

  • 1Director of Basic Research, InBio, 700 Harris Street, Charlottesville, VA 22903, USA.

Molecular Immunology
|March 17, 2023
PubMed
Summary

Cockroach allergens are identified and studied to understand their role in asthma development. Research focuses on allergen structure and IgE binding sites to design reduced reactivity molecules for improved allergy diagnosis and immunotherapy.

Keywords:
AllergensAsthmaB/T cell reactivityCockroach allergyDiagnosisImmunotherapy

More Related Videos

The Madagascar Hissing Cockroach as an Alternative Non-mammalian Animal Model to Investigate Virulence, Pathogenesis, and Drug Efficacy
12:21

The Madagascar Hissing Cockroach as an Alternative Non-mammalian Animal Model to Investigate Virulence, Pathogenesis, and Drug Efficacy

Published on: November 24, 2017

11.1K
Antigenic Liposomes for Generation of Disease-specific Antibodies
10:31

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

12.4K

Related Experiment Videos

Last Updated: Aug 6, 2025

Removal and Replacement of Endogenous Ligands from Lipid-Bound Proteins and Allergens
09:09

Removal and Replacement of Endogenous Ligands from Lipid-Bound Proteins and Allergens

Published on: February 24, 2021

3.0K
The Madagascar Hissing Cockroach as an Alternative Non-mammalian Animal Model to Investigate Virulence, Pathogenesis, and Drug Efficacy
12:21

The Madagascar Hissing Cockroach as an Alternative Non-mammalian Animal Model to Investigate Virulence, Pathogenesis, and Drug Efficacy

Published on: November 24, 2017

11.1K
Antigenic Liposomes for Generation of Disease-specific Antibodies
10:31

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

12.4K

Area of Science:

  • Immunology and Allergy
  • Environmental Health

Background:

  • Cockroach allergy is a significant risk factor for asthma development.
  • Over 20 official cockroach allergen groups are recognized by the WHO/IUIS.
  • Understanding allergen structure and function is crucial for managing allergic diseases.

Purpose of the Study:

  • To review the identification and characterization of cockroach allergens.
  • To discuss advancements in understanding allergen-specific immune responses.
  • To highlight the potential for novel diagnostic and therapeutic strategies in cockroach allergy.

Main Methods:

  • Analysis of allergen structure and function using techniques like X-ray crystallography.
  • Identification of IgE binding sites on cockroach allergens.
  • Component-resolved diagnostics assessing B and T cell reactivity.
  • Review of recent immunotherapy trials, such as CRITICAL.

Main Results:

  • Detailed characterization of several cockroach allergens, including their structure and function.
  • Identification of specific IgE binding sites enabling the design of hypoallergens.
  • Advancements in understanding T cell responses to cockroach allergens.
  • Insights from the CRITICAL trial on immunotherapy efficacy and immune response.

Conclusions:

  • Continued research on cockroach allergens is vital for advancing allergy diagnosis and treatment.
  • Molecular-level understanding of allergens facilitates the development of targeted immunotherapies.
  • Future directions include refining component-based diagnostics and personalized immunotherapy approaches.