Aortico-pulmonary bodies in the domestic fowl: ultrastructure, innervation and secretion

In adult and immature domestic fowl, aggregations of large pale-staining cells were found in the wall of the aorta, and of the pulmonary trunk and arteries, in modified regions typified by interruption or loss of elastic laminae and smooth muscle cells. Encapsulated extramural aggregations of similar cells were identified either on the actual surface or well outside the arterial wall of the aorta, and pulmonary trunk and arteries. The electron microscope revealed that the pale cells in these intramural and extramural structures were granular cells characterised by dense-cored vesicles typically about 60-140 nm in diameter. Supporting cells partly invested the granular cells. These intramural and extramural structures are interpreted as aortico-pulmonary bodies. The extramural and to a lesser extent the intramural cells were associated with many axonal endings and fenestrated blood capillaries. The axonal endings formed presumptive afferent, efferent and reciprocal synapses with the granular cells. Both intra- and extramural granular cells displayed evidence of exocytosis and were also shown by autoradiography to handle amines. It is concluded that the ultrastructural features of these aortico-pulmonary bodies resemble those of the carotid body. It is therefore suggested that the aortico-pulmonary bodies of the domestic fowl have a chemoreceptor function similar to that of the carotid body. It is also suggested that they may have a general secretory function.