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Current development of β-carboline derived potential antimalarial scaffolds
Preeti Kushwaha1, Vipin Kumar2, Biswajit Saha1
1Amity Institute of Biotechnology, Amity University, Sector 125, Noida, 201303, Uttar Pradesh, India.
European Journal of Medicinal Chemistry
|March 17, 2023
Summary
β-Carboline alkaloids show promise as novel antimalarial drugs. This review details their scaffolds and mechanisms, offering insights for developing new therapeutics against malaria.
Area of Science:
- Medicinal Chemistry
- Pharmacology
- Natural Products Chemistry
Background:
- Malaria remains a significant global health challenge, particularly in developing nations, due to increasing drug resistance and vector proliferation.
- The urgent need for novel, effective antimalarial therapeutics is driven by the limitations of current treatments and the escalating impact of Plasmodium parasites.
- β-Carboline alkaloids, a class of nitrogen-based natural products, possess diverse pharmacological activities and are being investigated for their antimalarial potential.
Purpose of the Study:
- To comprehensively review clinical and preclinical antimalarial scaffolds containing the β-carboline moiety.
- To illustrate various natural and semi-synthetic β-carboline analogues reported between 2011 and 2021.
- To provide insights into the molecular mechanisms of action for β-carboline-based antimalarials.
Main Methods:
- Literature review of scientific articles published between 2011 and 2021.
- Systematic analysis of β-carboline structures with reported antimalarial activity.
- Compilation and illustration of natural and semi-synthetic β-carboline analogues.
Main Results:
- Identification of diverse β-carboline scaffolds with significant antimalarial activity in preclinical and clinical studies.
- Categorization of natural and semi-synthetic β-carboline derivatives based on their structural features and reported efficacy.
- Summary of the various molecular targets and mechanisms through which β-carbolines exert their antimalarial effects.
Conclusions:
- β-Carboline alkaloids represent a promising class of compounds for the development of next-generation antimalarial drugs.
- Understanding the structure-activity relationships and mechanisms of action is crucial for optimizing β-carboline-based antimalarial therapeutics.
- This review serves as a valuable resource for researchers aiming to develop novel β-carboline-derived treatments to combat malaria.
