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Humanized Mediator Release Assay as a Read-Out for Allergen Potency
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Histamine intolerance.

Roman Hakl, Jiří Litzman

    Vnitrni Lekarstvi
    |March 17, 2023
    PubMed
    Summary

    Histamine intolerance (HIT) is a condition where the body cannot properly break down histamine, leading to various symptoms. A low-histamine diet is key for diagnosis and treatment.

    Area of Science:

    • Gastroenterology and Immunology
    • Clinical Nutrition

    Background:

    • Histamine intolerance (HIT) is a non-immunological condition resulting from impaired histamine metabolism.
    • HIT presents with diverse gastrointestinal and non-gastrointestinal symptoms, often mimicking other diseases like allergies or mastocytosis.
    • Accurate diagnosis of HIT is challenging due to non-specific symptoms and questionable reliability of current diagnostic tests for diamine oxidase (DAO) insufficiency.

    Approach:

    • This review focuses on the etiology, diagnostic challenges, and therapeutic strategies for histamine intolerance.
    • The diagnostic approach emphasizes the clinical response to a low-histamine diet as the primary indicator.
    • Treatment primarily involves dietary management, with DAO supplementation, antihistamines, and probiotics considered as adjunctive therapies.

    Key Points:

    Keywords:
    diamine oxidase (DAO)histamine intolerancehistamine intoxication

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    • The clinical presentation of HIT is highly variable and non-specific.
    • Reliable diagnostic markers for DAO insufficiency are currently lacking.
    • A low-histamine diet is the cornerstone for both diagnosing and managing HIT.

    Conclusions:

    • Histamine intolerance requires careful clinical evaluation due to its complex presentation.
    • Dietary modification is the most effective strategy for managing HIT symptoms.
    • Further research is needed to develop more definitive diagnostic tools for histamine intolerance.