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Related Experiment Videos

Heterogeneous lung emptying during forced expiration.

J J McNamara1, R G Castile, G M Glass

  • 1Department of Pediatrics, Children's Hospital, Boston, Massachusetts 02115.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|October 1, 1987
PubMed
Summary

The healthy canine lung empties heterogeneously, not homogeneously, during forced deflation. This complex regional emptying pattern is masked by interdependence, appearing uniform on maximum expiratory flow-volume curves.

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Area of Science:

  • Pulmonary Physiology
  • Respiratory Mechanics

Background:

  • Mammalian lung emptying is often assumed to be homogeneous during forced deflation.
  • Airway structure exhibits significant heterogeneity, making homogeneous emptying seem implausible.

Purpose of the Study:

  • To re-examine the homogeneity of lung emptying during forced deflation.
  • To investigate mechanisms controlling differential regional emptying.

Main Methods:

  • Studied 12 excised canine lungs.
  • Measured regional alveolar pressure and lung volume using a capsule technique during flow-limited deflations.
  • Assessed interregional pressure differences as an index of emptying nonuniformity.

Main Results:

  • Interregional pressure differences, indicating nonuniformity, were observed.

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  • These differences increased earlier in deflation.
  • Differential regional emptying patterns were detected, not apparent on maximum expiratory flow-volume curves.

    • Conclusions:

    • Healthy excised canine lungs exhibit a small degree of heterogeneous emptying.
    • This heterogeneous emptying occurs in an interdependent, compensatory pattern.
    • This pattern is masked on the maximum expiratory flow-volume curve.