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Effect of training/detraining on submaximal exercise responses in humans
R L Moore1, E M Thacker, G A Kelley
1Department of Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.
Journal of Applied Physiology (Bethesda, Md. : 1985)
|November 1, 1987
Summary
Endurance training boosts maximal aerobic power in sedentary individuals, but detraining doesn't reverse this. Muscle mitochondrial content, indicated by citrate synthase activity, influences fuel use during exercise.
Area of Science:
- Exercise Physiology
- Skeletal Muscle Metabolism
- Mitochondrial Adaptations
Background:
- Endurance training enhances maximal aerobic power (V02max) and skeletal muscle mitochondrial capacity.
- The impact of detraining on these adaptations, particularly in relation to substrate utilization, requires further elucidation.
Purpose of the Study:
- To investigate the effects of a training and detraining paradigm on V02max, skeletal muscle citrate synthase (CS) activity, and respiratory exchange ratio (RER) during submaximal exercise.
- To determine the relationship between mitochondrial content and substrate utilization during exercise.
Main Methods:
- A 7-week training followed by 3-week detraining protocol was implemented in previously sedentary (Group S) and trained (Group T) subjects.
- Measurements included V02max, vastus lateralis muscle CS activity, and RER at 60% V02max (R60).
Main Results:
- Training increased V02max and CS activity in Group S; detraining did not affect V02max but decreased CS activity. Group T showed no changes in V02max or CS activity with training, but detraining decreased CS activity.
- R60 decreased with training and increased with detraining in Group S. R60 was unaffected by training in Group T but increased with detraining.
- R60 changes correlated with CS activity changes but not V02max changes.
Conclusions:
- Mitochondrial content in skeletal muscle is a key determinant of substrate utilization during submaximal exercise.
- Detraining significantly reduces skeletal muscle mitochondrial capacity, impacting substrate utilization.
- While training improves aerobic capacity, the maintenance of mitochondrial adaptations is crucial for sustained metabolic benefits.
Keywords:
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