Antibiotic associated diarrhea in outpatient pediatric antibiotic therapy
Sevgen Tanır Basaranoğlu1, Ayşe Karaaslan2, Enes Salı3
1Department of Pediatric Infectious Diseases, Hacettepe University Faculty of Medicine, Ankara, 06100, Turkey.
Insights
Antibiotic-associated diarrhea (AAD) is a common side effect in children. This study found AAD occurred in 10.4% of pediatric patients, with higher rates in specific Turkish regions.
Area of Science:
- Pediatric Gastroenterology
- Infectious Diseases
- Clinical Epidemiology
Background:
- Antibiotic-associated diarrhea (AAD) is a frequent adverse effect of antimicrobial therapy.
- Understanding AAD epidemiology in pediatric populations is crucial for patient management.
Purpose of the Study:
- To assess the epidemiological data of antibiotic-associated diarrhea in pediatric patients within a specific region.
- To identify geographical variations in AAD occurrence.
Main Methods:
- A prospective, multi-center study involving pediatric patients receiving oral antibiotics.
- Patients were monitored for eight weeks via a surveillance system including physician inclusion, family charts, and telephone follow-up.
Main Results:
- 758 pediatric cases were analyzed, with an overall AAD incidence of 10.4%.
- Amoxicillin-clavulanate and cephalosporin use were associated with AAD rates of 10.4% and 14.4%, respectively.
- AAD occurrence varied significantly by geographical region (p=0.014), with higher rates in Eastern and Southeastern Anatolia.
Conclusions:
- The study provides key epidemiological insights into pediatric AAD in the region.
- Geographical disparities in AAD incidence were observed, highlighting the need for localized surveillance and management strategies.
Background:
Antibiotic-associated diarrhea is one of the most frequent side effects of antimicrobial therapy. We assessed the epidemiological data of antibiotic-associated diarrhea in pediatric patients in our region.
Methods:
The prospective multi-center study included pediatric patients who were initiated an oral antibiotic course in outpatient clinics and followed in a well-established surveillance system. This follow-up system constituded inclusion of patient by the primary physician, supply of family follow-up charts to the family, passing the demographics and clinical information of patient to the Primary Investigator Centre, and a close telephone follow-up of patients for a period of eight weeks by the Primary Investigator Centre.
Results:
A result of 758 cases were recruited in the analysis which had a frequency of 10.4% antibiotic-associated diarrhea. Among the cases treated with amoxicillin-clavulanate 10.4%, and cephalosporins 14.4% presented with antibiotic-associated diarrhea. In the analysis of antibiotic-associated diarrhea occurrence according to different geographical regions of Turkey, antibiotic-associated diarrhea episodes differed significantly (p = 0.014), particularly higher in The Eastern Anatolia and Southeastern Anatolia. Though most commonly encountered with cephalosporin use, antibiotic-associated diarrhea is not a frequent side effect.
Conclusion:
This study on pediatric antibiotic-associated diarrhea displayed epidemiological data and the differences geographically in our region.
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