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The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

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Tumor Therapy Strategies Based on Microenvironment-Specific Responsive Nanomaterials.

Zhaocong Zhang¹, Chengwen Ding¹, Tiedong Sun¹

¹Key Laboratory of Forest Plant Ecology, Ministry of Education, College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, 150040, China.

Advanced Healthcare Materials

|March 18, 2023

Summary

This study reviews tumor microenvironment (TME)-responsive nanomaterials for cancer treatment. It details TME characteristics, nanomaterial strategies, and their clinical potential for improved diagnosis and therapy.

Keywords:

nanomaterials specific targeting therapy tumor microenvironments

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Published on: March 25, 2019

Area of Science:

Biomedical Engineering
Nanotechnology
Oncology

Background:

The tumor microenvironment (TME) presents unique characteristics like hypoxia, low pH, and altered enzyme activity.
Nanomaterials offer targeted therapeutic strategies, but TME complexity necessitates tailored responses.
Understanding TME-specific nanomaterial interactions is crucial for effective cancer treatment.

Purpose of the Study:

To systematically review recent advances in TME-responsive nanomaterials for cancer therapy.
To outline and analyze various TME response strategies and their mechanisms.
To provide future perspectives on TME-responsive nanomaterial applications in oncology.

Main Methods:

Comprehensive literature review of TME characteristics and responsive nanomaterials.
Analysis of different TME-responsive strategies, including their advantages and disadvantages.
Synthesis of current research findings and identification of emerging trends.

Main Results:

Detailed summary of key TME features influencing nanomaterial behavior.
Categorization and evaluation of diverse TME-responsive nanomaterial strategies.
Identification of promising nanomaterial designs for enhanced tumor targeting and treatment efficacy.

Conclusions:

TME-responsive nanomaterials represent a significant advancement in targeted cancer therapy.
Tailoring nanomaterial responses to specific TME conditions is key to maximizing therapeutic outcomes.
These strategies hold substantial promise for future clinical applications in cancer diagnosis and treatment.