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The Cochlea

The Cochlea

The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.

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Related Experiment Video

Updated: Aug 6, 2025

Immunolabeling and Counting Ribbon Synapses in Young Adult and Aged Gerbil Cochleae

Immunolabeling and Counting Ribbon Synapses in Young Adult and Aged Gerbil Cochleae

Published on: April 21, 2022

Single-cell transcriptomic atlas of mouse cochlear aging.

Guoqiang Sun^1,2, Yandong Zheng^1,2, Xiaolong Fu³

¹State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.

|March 18, 2023

Summary

This summary is machine-generated.

Cochlear aging involves loss of protein stability and increased cell death, impacting hearing. Upregulating HSP90AA1 protein may reduce cellular stress and slow age-related hearing loss.

Keywords:

aging cochlea mouse single-cell transcriptomic atlas

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Last Updated: Aug 6, 2025

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Cochlear Surface Preparation in the Adult Mouse

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Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages

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Published on: April 11, 2025

Area of Science:

Otolaryngology
Cellular Biology
Molecular Biology

Background:

Age-related hearing loss (ARHL) is a progressive decline in cochlear function.
The cellular and molecular mechanisms driving cochlear aging are not well understood.

Purpose of the Study:

To create a detailed map of cellular and molecular changes during mouse cochlear aging.
To identify key molecular pathways and cell types involved in cochlear aging.

Main Methods:

Single-cell transcriptomic analysis of mouse cochlea across five time points.
Characterization of aging-associated gene expression in 27 distinct cochlear cell types.

Main Results:

Identified loss of proteostasis and increased apoptosis as hallmarks of cochlear aging.
Observed unique age-related transcriptional changes in stria vascularis intermediate cells.
Found that increased HSP90AA1 expression mitigates endoplasmic reticulum (ER) stress.

Conclusions:

Targeting the unfolded protein response (UPR) may combat ER stress and stria vascularis atrophy.
Interventions aimed at UPR pathways could potentially delay the progression of age-related hearing loss.