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Assessing the Viability of a Synthetic Bacterial Consortium on the In Vitro Gut Host-microbe Interface

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Postbiotics Implication in the Microbiota-Host Intestinal Epithelial Cells Mutualism.

Harpreet Kaur¹, Gurjeet Kaur^2,3, Syed Azmal Ali^4,5

¹Animal Biochemistry Division, ICAR-NDRI, Karnal, 132001, India.

Probiotics and Antimicrobial Proteins

|March 18, 2023

Summary

Post-biotics, like p40, activate the EGF receptor in intestinal cells, promoting gut health. Neonatal exposure reprograms cells for long-term protection against colitis by boosting regulatory T cells.

Keywords:

Dysbiosis Intestinal health Lactobacillus Postbiotics Probiotics

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Published on: August 30, 2016

Area of Science:

Gut microbiota and host interactions
Intestinal epithelial cell (IEC) biology
Immunology and inflammation

Background:

Host-microbiota interactions are crucial for intestinal homeostasis.
Commensal bacteria and IECs form the first line of defense.
Post-biotics, such as p40, regulate IECs and offer protective effects.

Conclusions:

Post-biotic factors play a significant role in maintaining intestinal health and homeostasis.
The crosstalk between IECs and post-biotic factors warrants further investigation.
More research is needed to establish the clinical efficacy of post-biotics for gut health.