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Metabolic reprogramming and interventions in endometrial carcinoma.

Jiajia Li1, Hongmei Yang2, Lingyi Zhang3

  • 1The Laboratory of Cancer Precision Medicine, the First Hospital of Jilin University, Changchun, Jilin 130061, China; Department of Gynecologic Oncology, Gynecology and Obstetrics Center, the First Hospital of Jilin University, Changchun, Jilin 130012, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
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Cancer cells reprogram metabolism for growth. This review explores how targeting energy pathways like glycolysis and oxidative phosphorylation offers new endometrial carcinoma treatment strategies.

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Area of Science:

  • Oncology
  • Metabolic Research
  • Cancer Cell Biology

Background:

  • Cancer cells exhibit metabolic adaptations crucial for growth, invasion, and metastasis.
  • While aerobic glycolysis (Warburg effect) is recognized, oxidative phosphorylation (OXPHOS) is increasingly implicated in cancer metabolism.
  • Metabolic syndromes are linked to increased endometrial carcinoma (EC) risk, highlighting metabolism's role in EC development.

Purpose of the Study:

  • To comprehensively review the relationship between cellular metabolism and endometrial carcinoma (EC).
  • To provide insights into novel therapeutic strategies targeting energy metabolism pathways in EC.
  • To explore the potential of metabolic targeting for overcoming chemotherapy resistance in EC.

Main Methods:

  • Literature review of current research on cancer metabolism and endometrial carcinoma.
  • Analysis of metabolic reprogramming in different EC cell types, including cancer stem cells and resistant cells.
  • Examination of the role of glycolysis and OXPHOS in EC progression and treatment response.

Main Results:

  • Metabolic preferences, including glycolysis and OXPHOS, vary among EC cell types.
  • Glycolysis is often the primary energy source in EC, with reduced OXPHOS.
  • Targeting glycolysis and OXPHOS pathways can inhibit EC tumor growth and enhance chemosensitization.

Conclusions:

  • Metabolic reprogramming is a key feature of EC, influencing its development and progression.
  • Targeting specific metabolic pathways (glycolysis, OXPHOS) presents promising avenues for EC therapy.
  • Interventions like metformin and weight management show potential in reducing EC incidence and improving patient outcomes, particularly when combined with chemotherapy.