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Related Experiment Video

Updated: Aug 6, 2025

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

Cardiac hypertrophy simulations using parametric and echocardiography-based left ventricle model with shell finite

Bogdan Milićević¹, Miljan Milošević², Vladimir Simić³

¹Faculty of Engineering, University of Kragujevac, Kragujevac, 34000, Serbia; Bioengineering Research and Development Center (BioIRC), Kragujevac, 34000, Serbia.

Computers in Biology and Medicine

|March 18, 2023

Summary

This study simulates cardiac hypertrophy using advanced shell element models. The research differentiates between eccentric and concentric hypertrophy, revealing distinct impacts on heart wall thickness and overall function.

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Last Updated: Aug 6, 2025

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Published on: February 13, 2021

In Silico Clinical Trials for Cardiovascular Disease

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Creating a Structurally Realistic Finite Element Geometric Model of a Cardiomyocyte to Study the Role of Cellular Architecture in Cardiomyocyte Systems Biology

Creating a Structurally Realistic Finite Element Geometric Model of a Cardiomyocyte to Study the Role of Cellular Architecture in Cardiomyocyte Systems Biology

Published on: April 18, 2018

Area of Science:

Cardiovascular Mechanics
Biomedical Engineering
Computational Biology

Background:

Cardiac hypertrophy, a significant heart condition, alters ventricular geometry and function.
Existing 3D models for cardiac simulation are often computationally intensive and complex.
Understanding the mechanical differences between eccentric and concentric hypertrophy is crucial for diagnosis and treatment.

Purpose of the Study:

To develop and validate a simplified yet accurate computational model for simulating cardiac hypertrophy.
To investigate the distinct effects of eccentric and concentric hypertrophy on left ventricular (LV) mechanics and shape.
To utilize patient-specific geometry for realistic cardiac modeling.

Main Methods:

Simulated cardiac hypertrophy using parametric and echocardiography-based left ventricle (LV) models with shell elements.
Employed a recently developed material model based on Holzapfel experiments to simulate passive stresses.
Developed novel, simplified shell composite finite element models for cardiac mechanics.

Main Results:

Successfully computed and differentiated the effects of eccentric and concentric hypertrophy.
Observed wall thickening associated with concentric hypertrophy and wall thinning with eccentric hypertrophy.
Demonstrated that the shell composite models are smaller and simpler than conventional 3D models.

Conclusions:

The developed shell element models provide an efficient and accurate method for simulating cardiac hypertrophy.
The patient-specific modeling approach based on echocardiography offers a foundation for practical clinical applications.
This computational tool offers valuable insights into hypertrophy development and can aid in testing medical hypotheses related to heart disease progression.