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Genome-wide polygenic risk scores for hypertensive disease during pregnancy can also predict the risk for long-term

Seung Mi Lee1, Manu Shivakumar2, Brenda Xiao2

  • 1Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, Korea.

American Journal of Obstetrics and Gynecology
|March 18, 2023
PubMed

Insights

Genetic predisposition for hypertensive disorders during pregnancy predicts long-term cardiovascular disease risk. High genetic risk is linked to increased atherosclerotic cardiovascular disease, including coronary artery disease and myocardial infarction.

Area of Science:

  • Cardiovascular epidemiology
  • Genetics of cardiovascular disease
  • Reproductive health

Background:

  • Hypertensive disorders during pregnancy (HDP) are linked to future cardiovascular disease (CVD).
  • The role of genetic predisposition for HDP in predicting long-term CVD risk remains unclear.

Purpose of the Study:

  • To assess the association between polygenic risk scores for HDP and long-term atherosclerotic cardiovascular disease (ASCVD) risk.
  • To determine if genetic risk for HDP can predict ASCVD development later in life.

Main Methods:

  • UK Biobank participants (n=164,575) of European descent with live births were analyzed.
  • Participants were stratified by polygenic risk scores for HDP into low, medium, and high-risk groups.
  • Incident ASCVD (coronary artery disease, myocardial infarction, ischemic stroke, peripheral artery disease) was evaluated.

Main Results:

  • Women with high genetic risk for HDP had higher baseline hypertension prevalence.
  • High genetic risk for HDP was associated with increased ASCVD risk, including coronary artery disease, myocardial infarction, and peripheral artery disease.
  • This association persisted even after adjusting for a history of HDP.

Conclusions:

  • High genetic risk for HDP is a significant predictor of future ASCVD.
  • Polygenic risk scores for HDP offer valuable insights into predicting long-term cardiovascular outcomes.
Abstract

Keywords:
cardiovascular outcomehypertensive disease during pregnancylong-term outcomespolygenic risk scorepreeclampsia

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