Adult-onset Coats disease.

Area of Science:

• Ophthalmology
• Retinal Vascular Diseases

Background:

• Coats disease is an idiopathic retinal vasculopathy.
• It typically affects young males, featuring retinal telangiectasia, aneurysms, and exudation.
• An adult-onset variant exists with distinct characteristics.

Purpose of the Study:

• To review the clinical features, pathogenesis, diagnostic methods, and treatment options for adult-onset Coats disease.
• To highlight the differences between adult and pediatric presentations.
• To provide a comprehensive overview for clinicians managing this condition.

Main Methods:

• Literature review of adult-onset Coats disease.
• Analysis of clinical presentations, imaging, and treatment outcomes.
• Synthesis of current knowledge on pathogenesis and management.

Main Results:

• Adult-onset Coats disease shows slower progression and localized lipid deposition.
• Peripheral and juxta-macular involvement are common.
• Management strategies are adapted for adult patients.

Conclusions:

• Adult-onset Coats disease requires specific diagnostic and therapeutic considerations.
• Early recognition and tailored treatment are crucial for visual prognosis.
• Further research may elucidate unique pathogenic mechanisms in adults.