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Updated: Aug 6, 2025

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Regulatory effect of orexin system on various diseases through mTOR signaling pathway

Ying Song1, Beibei Wang1, Wenjun Wang1

  • 1Department of Pharmacology, Zhejiang University of Technology, Hangzhou, Zhejiang, China.

Trends in Endocrinology and Metabolism: TEM
|March 18, 2023
PubMed

Insights

The orexin system regulates physiological functions and activates the mTOR pathway. This review explores how drugs targeting orexin signaling indirectly impact mTOR in various diseases.

Area of Science:

  • Neuroscience
  • Cellular Signaling
  • Pharmacology

Background:

  • Orexin (OX)A and OXB are neuropeptides from the lateral hypothalamus.
  • The orexin system regulates feeding, sleep-wake states, energy homeostasis, reward, and emotion.
  • Mammalian target of rapamycin (mTOR) is crucial for cellular processes and downstream of orexin signaling.

Purpose of the Study:

  • To review the association between the orexin system and the mTOR signaling pathway.
  • To discuss how drugs affecting the orexin system indirectly influence mTOR signaling in disease contexts.

Main Methods:

  • Literature review of studies investigating orexin, mTOR, and drug effects.
  • Analysis of the interplay between orexin receptor pathways and mTOR activation.
  • Discussion of indirect effects of pharmacological interventions on the orexin-mTOR axis.

Main Results:

  • The orexin system activates mTOR signaling.
  • Drugs targeting the orexin system can indirectly modulate mTOR activity.
  • This interaction is relevant across various disease states.

Conclusions:

  • The orexin system and mTOR pathway are interconnected.
  • Pharmacological modulation of orexin signaling offers a potential indirect route to influence mTOR.
  • Understanding this crosstalk is vital for therapeutic strategies in diverse diseases.
Keywords:
cerebral ischemia–reperfusion injurymammalian target of rapamycinorexinorexinergic receptor

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