Related Experiment Video
Updated: Aug 22, 2026
Quantitative 3D In Silico Modeling q3DISM of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease
Published on: December 26, 2016
CCR3 plays a role in murine age-related cognitive changes and T-cell infiltration into the brain
Sanket V Rege1, Arnaud Teichert2, Juliet Masumi1
1Alkahest, Inc., San Carlos, CA, USA.
Abstract:
Targeting immune-mediated, age-related, biology has the potential to be a transformative therapeutic strategy. However, the redundant nature of the multiple cytokines that change with aging requires identification of a master downstream regulator to successfully exert therapeutic efficacy. Here, we discovered CCR3 as a prime candidate, and inhibition of CCR3 has pro-cognitive benefits in mice, but these benefits are not driven by an obvious direct action on central nervous system (CNS)-resident cells. Instead, CCR3-expressing T cells in the periphery that are modulated in aging inhibit infiltration of these T cells across the blood-brain barrier and reduce neuroinflammation. The axis of CCR3-expressing T cells influencing crosstalk from periphery to brain provides a therapeutically tractable link. These findings indicate the broad therapeutic potential of CCR3 inhibition in a spectrum of neuroinflammatory diseases of aging.
Insights
Targeting chemokine receptor 3 (CCR3) shows promise for age-related diseases. Inhibiting CCR3 in mice improved cognition by reducing T cell infiltration into the brain, offering a new therapeutic avenue for neuroinflammation.
Area of Science:
- Immunology
- Neuroscience
- Aging Research
Background:
- Age-related immune dysregulation presents therapeutic challenges due to cytokine redundancy.
- Identifying master regulators is crucial for effective interventions in aging biology.
Purpose of the Study:
- To identify a master downstream regulator in immune-mediated aging processes.
- To investigate the therapeutic potential of targeting this regulator, specifically chemokine receptor 3 (CCR3).
Main Methods:
- Discovery of CCR3 as a key regulator in aging immune responses.
- Assessment of CCR3 inhibition effects on cognitive function in mouse models.
- Analysis of T cell infiltration across the blood-brain barrier and neuroinflammation markers.
Main Results:
- CCR3 inhibition demonstrated pro-cognitive benefits in aged mice.
- These benefits were mediated by peripheral CCR3-expressing T cells, not direct central nervous system (CNS) action.
- Modulated T cells inhibited CNS infiltration, reducing neuroinflammation.
Conclusions:
- The CCR3-expressing T cell axis offers a therapeutically targetable link between the periphery and the brain.
- CCR3 inhibition presents a promising strategy for treating neuroinflammatory diseases associated with aging.
More Related Videos
07:26High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
Published on: July 18, 2017
09:55Isolation and Characterization of the Immune Cells from Micro-dissected Mouse Choroid Plexuses
Published on: February 3, 2022
