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A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
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Circular RNA regulation and function in drug seeking phenotypes.

Stephanie E Daws1, Aria Gillespie1

  • 1Center for Substance Abuse Research, Temple University, Philadelphia, PA, USA; Department of Neural Sciences, Temple University, Philadelphia, PA, USA.

Molecular and Cellular Neurosciences
|March 19, 2023
PubMed
Summary

Drug addiction alters brain cells by affecting circular RNAs (circRNAs), which are understudied RNA molecules. Understanding circRNA changes offers new therapeutic targets for addiction and overdose risk.

Keywords:
Circular RNACocaineHeroinMorphineOpioidPsychostimulantSplicing

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Area of Science:

  • Neurobiology
  • Molecular Biology
  • Genetics

Background:

  • Drug overdoses are a leading cause of accidental death in the US.
  • Understanding neurobiological changes from drug exposure is key for developing therapies.
  • Messenger RNAs (mRNAs) show drug-induced gene patterns, but other RNAs like circular RNAs (circRNAs) are understudied.

Purpose of the Study:

  • To review circRNA function and their role in drug seeking behavior.
  • To highlight how drug-induced circRNA dysregulation impacts addiction.
  • To discuss adapting circRNA biology principles for addiction research.

Main Methods:

  • Literature review of circRNA function and regulation.
  • Analysis of studies on drug-induced circRNA changes in the brain.
  • Discussion of circRNA mechanisms in relation to addiction phenotypes.

Main Results:

  • Chronic drug exposure induces molecular neuroadaptations, including changes in circRNAs.
  • circRNAs are enriched in the nervous system and play diverse cellular roles.
  • Emerging evidence suggests circRNAs are involved in cognition and are regulated by drug exposure.

Conclusions:

  • circRNAs are a significant, understudied class of molecules impacted by drug exposure.
  • Dysregulation of circRNAs may contribute to the neurobiology of addiction.
  • Further research into circRNAs can provide novel insights and therapeutic strategies for addiction.