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Correlation between serum cystatin C and lipid level in patients with chronic heart failure
1Department of Cardiovascular Medicine, 521 Hospital of Norinco Group, Xi'an 710065. single520zx202201@126.com.
Insights
In chronic heart failure (CHF) patients, lower high-density lipoprotein (HDL) levels are linked to abnormal serum cystatin C (Cys C). This finding suggests HDL may be the sole blood lipid indicator associated with Cys C abnormalities in CHF.
Area of Science:
- Cardiology
- Clinical Biochemistry
- Nephrology
Background:
- Serum cystatin C (Cys C) and blood lipids are implicated in chronic heart failure (CHF).
- Limited research exists on the relationship between serum Cys C and blood lipids in CHF patients.
- Understanding this correlation can aid CHF diagnosis and treatment.
Purpose of the Study:
- To investigate the association between serum Cys C levels and blood lipid profiles in patients with CHF.
- To provide clinical insights for managing CHF.
Main Methods:
- 336 hospitalized CHF patients were categorized into Cys C normal (n=180) and abnormal (n=156) groups.
- General data, laboratory markers, and echocardiographic results were compared.
- Pearson correlation and multivariate logistic regression analyses were employed.
Main Results:
- The Cys C abnormal group exhibited lower left ventricular ejection fraction (LVEF), older age, and higher rates of diabetes and smoking.
- Abnormal Cys C was associated with elevated serum creatinine (SCr), blood urea nitrogen (BUN), and total bilirubin (TBIL).
- Serum Cys C showed negative correlations with high-density lipoprotein (HDL), apolipoprotein A (Apo A), and albumin (ALB).
Conclusions:
- Decreased HDL levels were identified as a risk factor for abnormal serum Cys C in CHF patients.
- Apo A was not found to be a risk factor for abnormal serum Cys C.
- HDL may be the primary blood lipid marker associated with serum Cys C abnormalities in CHF.
Objectives:
Serum cystatin C (Cys C) and blood lipid levels are related to the occurrence and development of chronic heart failure (CHF). However, there are few reports on the correlation between blood lipid level and serum Cys C level in patients with CHF. The aim of this study is to explore the correlation between serum Cys C level and blood lipid level in patients with CHF, and to provide valuable reference for clinical diagnosis and treatment of CHF.
Methods:
A total of 336 CHF patients who were hospitalized in the Department of Cardiovascular Medicine of Shaanxi Provincial People's Hospital from October 2017 to July 2018 were included and they were divided into a Cys C normal group (n=180) and a Cys C abnormal group (n=156) according to serum Cys C level of the patients. The general data, laboratory indicators, and cardiac ultrasound results were compared between the 2 groups. Pearson correlation analysis was used to detect the correlation between serum Cys C level and blood lipid level and other factors, and the data related to Cys C were further analyzed by multivariate logistic regression.
Results:
Compared with the Cys C normal group, patients in the Cys C abnormal group had lower left ventricular ejection fraction (LVEF) (P<0.001), older age (P=0.030), higher incidence rate of diabetes and smoking index (P=0.002 and P=0.003, respectively). The levels of serum creatinine (SCr), blood urea nitrogen (BUN), and total bilirubin (TBIL) were higher (all P<0.001), while the levels of high density lipoprotein (HDL), apolipoprotein (Apo) A, and albumin (ALB) were lower (P<0.001, P=0.001, and P=0.003, respectively) in the Cys C abnormal group. Pearson correlation analysis showed that serum Cys C level was negatively correlated with platelet count, HDL, Apo A, ALB, and LVEF. It was positively correlated with smoking index, mean platelet volume, neutrophil ratio, BUN, and TBIL (all P<0.05). The results of multivariate logistic regression analysis showed that the decreased HDL level was a risk factor for the abnormality of serum Cys C in patients with CHF (OR=0.119, P=0.003), while Apo A was not a risk factor for its abnormality (P=0.337).
Conclusions:
HDL might be the only blood lipid index associated with abnormal serum Cys C in patients with CHF.
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