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Published on: September 11, 2018
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Adverse effects related with norepinephrine through short peripheral venous access: Scoping review
J García-Uribe1, D Lopera-Jaramillo1, J Gutiérrez-Vargas2
1Facultad de Ciencias de la Salud, Corporación Universitaria Remington, Medellín, Colombia.
Enfermeria Intensiva
|March 19, 2023
Summary
Peripheral norepinephrine administration is associated with a low risk of complications, primarily extravasation. Close nursing assessment and specific treatments can manage adverse events effectively.
Area of Science:
- Critical Care Medicine
- Pharmacology
- Nursing Practice
Background:
- Peripheral administration of norepinephrine is often restricted due to concerns about extravasation and potential tissue necrosis.
- Understanding the adverse effects and administration characteristics is crucial for safe patient care.
Purpose of the Study:
- To conduct a scoping review on the adverse effects of norepinephrine administered via short peripheral venous access.
- To describe the characteristics of norepinephrine administration in intensive care, surgical, and emergency settings.
Main Methods:
- Scoping review methodology.
- Inclusion of 12 studies with diverse patient populations and characteristics.
- Analysis of adverse events, drug administration parameters, and management strategies.
Main Results:
- Complication rates were below 12% in observational studies, and below 2% with specific low doses and concentrations.
- The primary adverse event identified was extravasation; no cases of tissue necrosis were reported.
- Treatment for extravasation included phentolamine, terbutaline, or topical nitroglycerin, with administration times varying significantly.
Conclusions:
- Extravasation is the main adverse effect, but severe complications like tissue necrosis were absent.
- Phentolamine and terbutaline show promise in managing extravasation, highlighting the need for their availability.
- Continuous, close nursing assessment and comprehensive care are essential for patients receiving peripheral norepinephrine.
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