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Updated: Aug 6, 2025

Single-molecule Super-resolution Imaging of Phosphatidylinositol 4,5-bisphosphate in the Plasma Membrane with Novel Fluorescent Probes
Published on: October 15, 2016
Glycosphingolipid and Glycosylphosphatidylinositol Affect Each Other in and on the Cell
1Department of Chemistry, University of Florida, Gainesville, Florida, 32811, USA.
Abstract:
Glycosphingolipid (GSL) and glycosylphosphatidylinositol (GPI) are the two major glycolipids expressed by eukaryotic cells, and their metabolisms share the same machineries. Moreover, both GSLs and GPI-anchored proteins (GPI-APs) are localized in the cholesterol-rich regions, namely the lipid rafts, of the cell membrane, where many other signaling molecules are compartmentalized as well. Therefore, the interaction between GSLs and GPI-APs and their interactions with other molecules in the lipid rafts are inevitable. This review is focused on the influences of GSLs and GPI-APs on each other's biosynthesis, trafficking, cell membrane distribution, and biological functions, such as signal transduction.
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