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Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma
Published on: September 15, 2023
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Association between papillary thyroid carcinoma and lymphocytic thyroiditis: A retrospective study
Kai Wu1,2, Liuhong Shi2, Jianbiao Wang2
1Department of Otorhinolaryngology, Linping District First People's Hospital, Hangzhou, Zhejiang 311100, P.R. China.
Oncology Letters
|March 20, 2023
Summary
This study found that lymphocytic thyroiditis (LT) in papillary thyroid carcinoma (PTC) patients is linked to more female patients, multifocal tumors, and less extrathyroidal extension. LT also correlates with an increased risk of multifocality in PTC.
Area of Science:
- Endocrinology
- Oncology
- Pathology
Background:
- Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy.
- The coexistence of lymphocytic thyroiditis (LT) with PTC is frequently observed, but its impact on clinicopathological features requires further elucidation.
- Understanding these associations can refine prognostic assessments and treatment strategies for PTC.
Purpose of the Study:
- To investigate the relationship between coexisting lymphocytic thyroiditis (LT) and the clinicopathological characteristics of papillary thyroid carcinoma (PTC).
- To compare clinicopathological features of PTC in patients with and without LT, including Hashimoto's thyroiditis (HT) and non-Hashimoto's LT (NHLT).
Main Methods:
- Retrospective analysis of 458 patients with PTC who underwent total thyroidectomy and lymph node dissection.
- Classification of patients into three groups based on thyroid parenchyma histopathology: Hashimoto's thyroiditis (HT), non-Hashimoto's type LT (NHLT), and no LT.
- Comparison of clinicopathological data including age, sex, tumor size, multifocality, extrathyroidal extension, lymph node metastasis, and tumor grade across the groups.
Main Results:
- The prevalence of coexisting LT was 29.0%, with 7.6% being HT and 21.4% NHLT.
- PTC with LT showed significant associations with female sex, lower rates of extrathyroidal extension, lower central lymph node metastasis (CLNM) ratio, higher number of dissected lymph nodes, larger metastatic lymph nodes, higher multifocality, and earlier pT stage.
- LT was independently associated with multifocality in PTC (OR, 1.578; P=0.030).
Conclusions:
- Coexisting LT in PTC patients is associated with a higher prevalence in females, increased multifocality, reduced extrathyroidal extension, and a lower CLNM ratio.
- LT appears to be an independent risk factor for multifocality in papillary thyroid carcinoma.
- These findings highlight the clinical significance of recognizing LT in PTC patients for improved risk stratification.
