Related Experiment Video

Updated: Aug 6, 2025

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
04:01

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Published on: March 15, 2024

1.1K

Regulatory roles of ferroptosis-related non-coding RNAs and their research progress in urological malignancies

Shijin Wang1, Bowen Jiang1, Deqian Xie1

  • 1Department of Urology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.

Frontiers in Genetics
|March 20, 2023
PubMed

Insights

Ferroptosis-associated non-coding RNAs (ncRNAs) are key regulators in urological cancers. This review explores their role in disease progression and treatment, offering insights for future diagnostics and therapies.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Ferroptosis is a regulated cell death mechanism driven by lipid peroxidation.
  • Non-coding RNAs (ncRNAs) modulate gene expression across multiple levels.
  • Dysregulated ncRNAs are implicated in various disease pathologies.

Purpose of the Study:

  • To systematically review the role of ferroptosis-associated ncRNAs in urological malignancies.
  • To explore the involvement of ncRNAs in the occurrence, drug resistance, and prognosis of these cancers.
  • To provide insights for future diagnostic and therapeutic strategies.

Main Methods:

  • Literature review of ferroptosis-associated ncRNAs in urological cancers.
  • Analysis of the functions of long non-coding RNAs, microRNAs, and circular RNAs.
  • Synthesis of current evidence on their clinical relevance.

Main Results:

  • Ferroptosis-related ncRNAs significantly influence the development and progression of urological malignancies.
  • These ncRNAs are implicated in acquired resistance to anti-cancer drugs.
  • Specific ncRNAs show potential as prognostic biomarkers.

Conclusions:

  • Ferroptosis-associated ncRNAs represent promising targets for novel diagnostic and therapeutic interventions in urological cancers.
  • Further research is needed to overcome challenges in their clinical application.
  • Understanding these ncRNAs can enhance personalized treatment approaches.
Keywords:
bladder cancerferroptosiskidney cancernon-coding RNAsprostate cancerurological oncology

More Related Videos

Desthiobiotin-Streptavidin-Affinity Mediated Purification of RNA-Interacting Proteins in Mesothelioma Cells11:11

Desthiobiotin-Streptavidin-Affinity Mediated Purification of RNA-Interacting Proteins in Mesothelioma Cells

Published on: April 25, 2018

8.2K
Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients12:13

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

6.9K

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.7K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.1K
Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.0K
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
963
Translational Regulation01:29

Translational Regulation

Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...
53
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
35.5K