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Author Spotlight: Advancements in iPSCs and Genetic Disease Research
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Computational comparative analysis identifies potential stemness-related markers for mesenchymal stromal/stem cells.

Myret Ghabriel1, Ahmed El Hosseiny1,2,3, Ahmed Moustafa1,2,3

  • 1Biotechnology Graduate Program, American University in Cairo, New Cairo, Egypt.

Frontiers in Cell and Developmental Biology
|March 20, 2023
PubMed
Summary

Researchers identified proteasome degradation system genes as potential stemness markers for mesenchymal stromal/stem cells (MSCs). This discovery aids in accurately identifying MSCs for regenerative medicine applications.

Keywords:
gene interaction networksmesenchymal stem cellsproteasomestemness-related markerstranscriptomics

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Area of Science:

  • * Stem cell biology and regenerative medicine.

Background:

  • * Mesenchymal stromal/stem cells (MSCs) are multipotent cells with self-renewal and differentiation capabilities, making them valuable for regenerative therapies.
  • * Current International Society for Cellular Therapy (ISCT) criteria for MSC identification lack consistency across different tissue sources, hindering pure population isolation for therapeutic use.

Purpose of the Study:

  • * To identify novel gene markers for accurate mesenchymal stromal/stem cell (MSC) identification.
  • * To enhance the existing International Society for Cellular Therapy (ISCT) criteria for more reliable MSC characterization across diverse tissues.

Main Methods:

  • * Computational comparative analysis of gene expression in human and mouse MSCs from multiple tissues.
  • * Identification of differentially expressed genes shared between species.
  • * Validation using predictive models and analysis of genetic interaction networks.

Main Results:

  • * Six members of the proteasome degradation system showed consistent expression across MSCs from bone marrow, adipose tissue, amnion, and umbilical cord.
  • * Predictive models confirmed the efficacy of these proteasome genes in validating MSC identity across all tested tissue sources.
  • * A potential link between these proteasome genes and antioxidant enzymes in MSCs was identified, suggesting a role in MSC lifespan extension.

Conclusions:

  • * Members of the proteasome degradation system show potential as reliable stemness-related markers for mesenchymal stromal/stem cells (MSCs).
  • * These markers can improve the accuracy of MSC identification, facilitating their use in regenerative medicine.