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Crosstalk between cGAS-STING pathway and autophagy in cancer immunity

Qijun Lu1, Yukun Chen2, Jianwen Li1

  • 1Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Frontiers in Immunology
|March 20, 2023
PubMed

Insights

The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway and autophagy are interconnected, influencing cancer immunity. Understanding these interactions is crucial for developing novel cancer treatments.

Area of Science:

  • Immunology
  • Cell Biology
  • Oncology

Background:

  • The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway is vital for cancer immunity.
  • Autophagy, a cellular degradation process, plays a role in both innate and adaptive immunity.
  • Recent evidence suggests an interconnection between the cGAS-STING pathway and autophagy, potentially impacting cancer progression.

Purpose of the Study:

  • To systematically review and summarize recent findings on the cGAS-STING pathway and autophagy in cancer immunity.
  • To explore the interactions between cGAS-STING and autophagy within the context of cancer immunity.
  • To provide an outlook on the combined therapeutic potential of cGAS-STING and autophagy in cancer treatment.

Main Methods:

  • Systematic literature review of recent findings.
  • Analysis of the interplay between cGAS-STING and autophagy in cancer immunity.
  • Exploration of potential synergistic therapeutic strategies.

Main Results:

  • The cGAS-STING pathway and autophagy are increasingly recognized for their roles in cancer immunity.
  • Interactions between cGAS-STING and autophagy, while not extensively studied, show potential influence on tumor progression.
  • The combined modulation of cGAS-STING and autophagy may offer novel therapeutic avenues for cancer.

Conclusions:

  • The relationship between cGAS-STING and autophagy is critical for understanding and enhancing cancer immunity.
  • Further research into these interactions is warranted to develop effective cancer immunotherapies.
  • Targeting both cGAS-STING and autophagy pathways could represent a promising strategy for cancer treatment.
Keywords:
antitumorautophagycGAS-STINGcancerimmunity

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