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Related Concept Videos

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
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Related Experiment Video

Updated: Aug 6, 2025

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility
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Regulation of microglia function by neural stem cells.

Monique M A de Almeida1,2, Kara Goodkey1,3, Anastassia Voronova1,2,3,4,5

  • 1Department of Medical Genetics, Faculty of Medicine & Dentistry, Edmonton, AB, Canada.

Frontiers in Cellular Neuroscience
|March 20, 2023
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Summary
This summary is machine-generated.

Neural stem cells (NSCs) regulate brain immune cells called microglia. This interaction is key for developing therapies to repair the central nervous system (CNS).

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NPCOPCimmunomodulatorymultiple sclerosisneuroinflammationneuroprotectionregenerationremyelination

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Area of Science:

  • Neuroscience
  • Immunology
  • Stem Cell Biology

Background:

  • Neural stem and precursor cells (NPCs) are crucial for central nervous system (CNS) development and repair.
  • Recent 'omics' studies reveal NPCs possess immune-related gene expression.
  • Microglia are key immune cells residing within NPC niches in the CNS.

Purpose of the Study:

  • To review the immunomodulatory functions of NPCs on microglia.
  • To explore how NPCs influence microglial fate in various CNS conditions.
  • To identify NPC-derived mediators of microglial regulation.

Main Methods:

  • Literature review of studies on NPCs and microglia interactions.
  • Analysis of single-cell RNA sequencing and other 'omics' data.
  • Examination of NPC roles in developing, injured, and degenerating CNS models.

Main Results:

  • NPCs modulate microglial survival, proliferation, migration, phagocytosis, and activation.
  • Both transplanted and endogenous NPCs exhibit immunomodulatory effects.
  • Specific NPC-derived mediators influencing microglia biology have been identified.

Conclusions:

  • NPCs possess significant immunomodulatory properties impacting CNS health.
  • Understanding NPC-microglia interactions is vital for designing effective CNS regenerative therapies.
  • Targeting these interactions holds promise for treating neurodegenerative diseases.