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Updated: Aug 6, 2025
Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
Published on: August 1, 2018
Correlation Between Intensity of Vimentin Immuno-expression in Young Women with Triple Negative Breast Cancer and Its
Fitriani Lumongga1,2, Ridha Dharmajaya3, Kamal Basri Siregar4
1Philosophy Doctor in Medicine Program, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.
Background:
Young breast cancer patients (≤40 years) have different unifying oncogenic signaling pathways when compared to older people. Vimentin is a filament intermediate. Vimentin expression has an important role in epithelial-to-mesenchymal transition (EMT) and cancer progression.
Objective:
The aim of this study was to assess the correlation between vimentin intensity and clinicopathological parameters in patients with triple negative breast cancer aged 40 years.
Methods:
Samples were taken from 45 paraffin blocks of patients with young woman with triple negative invasive breast cancer NOS type that met the inclusion criteria, immunohistochemical examination was performed with vimentin. Vimentin intensity was assessed using ImageJ analysis.
Results:
Samples were taken from paraffin blocks of patients with triple negative invasive breast cancer NOS type that met the inclusion criteria, immunohistochemical examination was performed with vimentin. Vimentin intensity was assessed using ImageJ analysis.
Conclusion:
This study shows that vimentin intensity is strongly associated with tumor progression, tumor mass size and tumor invasion so that it can be used as a prognostic factor in young triple negative breast cancer patients.
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