Related Experiment Video
Updated: Aug 6, 2025
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Bladder Smooth Muscle Strip Contractility as a Method to Evaluate Lower Urinary Tract Pharmacology
Published on: August 18, 2014
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Comparison of Two Treatment Modalities in Overactive Bladder: A Rapid Overview
Abdulrahim A Mirza1, Mohammed A Alamoudi2, Ahmad A Mirza3,4
1Department of Surgery - Division of Urology, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Jeddah, Saudi Arabia.
Medical Archives (Sarajevo, Bosnia and Herzegovina)
|March 20, 2023
Summary
Sacral neuromodulation (SNM) and botulinum toxin (BTX) injections are comparable treatments for overactive bladder. SNM may be more effective for patients who have not responded to BTX therapy.
Area of Science:
- Urology
- Nephrology
- Neurology
Background:
- Overactive bladder (OAB) is characterized by urgency, often with frequency and nocturia, in the absence of infection.
- Sacral neuromodulation (SNM) and intravesical botulinum toxin (BTX) injections are established treatments for OAB refractory to conservative management.
Purpose of the Study:
- To provide an updated comparative overview of the efficacy and outcomes of BTX injections versus SNM for treating overactive bladder.
Main Methods:
- A systematic literature search was conducted on PubMed and Google Scholar from 2016 to 2022.
- Included studies focused on adult populations and compared BTX injection with SNM for OAB treatment.
Main Results:
- The overview included six articles with 648 participants.
- Both BTX and SNM demonstrated comparable efficacy in treating OAB, with no major complications reported.
- SNM showed greater success and patient satisfaction when used for OAB refractory to prior BTX treatment, compared to BTX following SNM failure.
Conclusions:
- This review offers a current comparative analysis of BTX and SNM for overactive bladder treatment.
- The findings suggest that while both modalities are effective, the sequence of treatment may influence outcomes, with SNM potentially offering advantages in refractory cases.
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