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The relationship between the pan-immune-inflammation value and long-term prognoses in patients with hypertension:

Bo Wu1, Chenlu Zhang1, Shuqiong Lin2

  • 1Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.

Frontiers in Cardiovascular Medicine
|March 20, 2023
PubMed

Insights

High pan-immune-inflammation value (PIV) indicates increased risk of death in hypertensive patients. This study links elevated PIV to higher all-cause and cardiovascular mortality, highlighting its potential as a prognostic marker.

Area of Science:

  • Cardiology
  • Immunology
  • Public Health

Background:

  • Hypertension management requires better risk stratification beyond cardiovascular disease (CVD) risk.
  • Immunity and inflammation significantly impact hypertension prognosis.
  • The pan-immune-inflammation value (PIV) is an emerging index for assessing immune-inflammatory status.

Purpose of the Study:

  • To investigate the association between PIV and long-term mortality in hypertensive patients.
  • To determine if PIV can serve as a predictor for all-cause and cardiovascular mortality.

Main Methods:

  • Analysis of data from the National Health and Nutrition Examination Survey (NHANES) 1999-2018.
  • Inclusion of 26,781 hypertensive participants with mortality follow-up through December 31, 2019.
  • Assessment of PIV's relationship with mortality using survival curves and Cox regression analysis.

Main Results:

  • A significant association was found between PIV levels and long-term all-cause and cardiovascular mortality.
  • Higher PIV levels were linked to an increased risk of all-cause mortality (HR: 1.37) and cardiovascular mortality (HR: 1.62).
  • These associations remained significant after full adjustment for potential confounders.

Conclusions:

  • Elevated PIV is a significant predictor of increased all-cause and cardiovascular mortality in hypertensive individuals.
  • PIV may offer valuable insights for identifying high-risk hypertensive patients.
  • Further research could explore PIV's role in guiding therapeutic strategies for hypertension.
Abstract

Keywords:
NHANESall-cause mortalitycardiovascular mortalityhypertensionpan-immune-inflammation value

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