Related Experiment Video
Updated: Aug 6, 2025
10:06
An Efficient Method for Adenovirus Production
Published on: June 10, 2021
13.8K
A nomogram for predicting severe adenovirus pneumonia in children
Jiamin Zhang1, Changdi Xu1, Shasha Yan1
1Department of Respiratory Medicine, Children's Hospital of Nanjing Medical University, Nanjing, China.
Frontiers in Pediatrics
|March 20, 2023
Summary
A new scale aids in the early identification of severe adenovirus pneumonia in children. This tool accurately predicts severe cases, improving pediatric respiratory health outcomes.
Area of Science:
- Pediatric infectious diseases
- Respiratory medicine
- Clinical diagnostics
Background:
- Adenoviral pneumonia significantly impacted children's health in China in 2019.
- A need exists for a systematic scale for early identification of pediatric adenoviral pneumonia.
Purpose of the Study:
- To establish and validate an early recognition scale for severe pediatric adenovirus pneumonia.
- To predict the risk of developing severe adenovirus pneumonia in children.
Main Methods:
- Analysis of clinical data from 132 children with adenoviral pneumonia.
- Univariate and multivariate logistic regression analyses of clinical parameters and imaging features.
- Construction of a predictive nomogram using identified scale indicators.
Main Results:
- Significant differences observed in age, respiratory rate, fever duration, neutrophil/lymphocyte percentages, CRP, ALT, and LDH between groups.
- Key indicators identified: respiratory rate, neutrophil percentage, lymphocyte percentage, and LDH.
- The developed scale demonstrated high sensitivity (93.3%) and specificity (92.1%) via ROC curve analysis.
Conclusions:
- The established scale effectively screens for early recognition of severe adenovirus pneumonia in children.
- This predictive tool aids in the early determination of disease severity, facilitating timely intervention.
More Related Videos
09:14An Improved and High Throughput Respiratory Syncytial Virus RSV Micro-neutralization Assay
Published on: January 26, 2019
11.0K
06:22Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS
Published on: April 7, 2021
3.5K
Related Concept Videos
01:30Pneumonia III: Complications and Assessment
320
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
320
01:21Acute Respiratory Failure-II
301
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
301
01:30Acute Respiratory Failure-III
241
Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without...
241
01:28Pneumonia IV: Management
409
The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
409
01:29Acute Respiratory Failure-V
174
The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Ensure that patients are monitored continuously for their response to therapy, including changes in...
174
01:23Acute Respiratory Failure-IV
185
Respiratory failure can manifest suddenly or gradually, characterized by a rapid decline in PaO2 and a rapid rise in PaCO2. This situation indicates a severe respiratory problem that may quickly become a life-threatening emergency. One of the early signs of hypoxemic Acute Respiratory Failure (ARF) is a change in mental status due to the brain's sensitivity to oxygen levels and changes in acid-base balance. Symptoms such as restlessness, confusion, and agitation suggest inadequate oxygen...
185