Adrenergic modulation of gastric stress pathology in rats: a cholinergic link

The effects of some adrenergic drugs were evaluated on cold restraint-induced gastric ulcers in rats. The beta-adrenergic antagonist, (+/-)-propranolol (1 and 10 mg/kg), as well as the beta-agonist, isoproterenol (0.05 and 0.5 mg/kg) potentiated the gastric pathology. On the other hand, the alpha-agonist, clonidine (0.5 mg/kg) attenuated and the alpha-antagonist, yohimbine (1 mg/kg) aggravated stress ulcer development. The anticholinergic agent, atropine methylnitrate (1 mg/kg), reduced both the frequency and severity of stress ulcers and also antagonized the potentiating effects of (+/-)-propranolol, isoproterenol and yohimbine. The results suggest a cholinergic role in the adrenergic modulation of gastric stress pathology.