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Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice
Published on: July 8, 2020
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Elevated Urinary IL-6 Predicts the Progression of IgA Nephropathy
Wenjun Zhao1,2,3,4, Shi Feng1,2,3,4, Yucheng Wang1,2,3,4
1Kidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, China.
Kidney International Reports
|March 20, 2023
Summary
Urinary interleukin-6 (IL-6) and transforming growth factor-β1 (TGF-β1) show promise in predicting Immunoglobulin A nephropathy (IgAN) progression. Elevated urinary IL-6 is an independent risk factor for IgAN progression.
Area of Science:
- Nephrology
- Immunology
- Biomarker Discovery
Background:
- Immunoglobulin A nephropathy (IgAN) is the most prevalent glomerulonephritis globally.
- Predicting IgAN progression and regression presents a significant clinical challenge.
- There is a critical need for reliable prognostic biomarkers in IgAN management.
Purpose of the Study:
- To identify and validate promising prognostic markers for IgAN.
- To evaluate the diagnostic and prognostic potential of specific cytokines in IgAN.
- To assess the association of urinary biomarkers with IgAN progression.
Main Methods:
- Serum and urinary cytokine levels were measured using cytokine antibody arrays in IgAN patients and healthy controls.
- Candidate biomarkers were validated in a multicenter cohort.
- Associations with IgAN progression were analyzed in a large cohort with long-term follow-up.
Main Results:
- Urinary interleukin-6 (IL-6) and transforming growth factor-β1 (TGF-β1) effectively distinguished IgAN patients from controls.
- Elevated urinary IL-6 and TGF-β1 levels were observed in IgAN patients with high discriminatory power (AUC 0.9725).
- Urinary IL-6 was independently correlated with an increased risk of composite renal outcome, while TGF-β1 did not show statistical significance.
Conclusions:
- Elevated urinary IL-6 and TGF-β1 levels are predictive of IgAN progression.
- Urinary IL-6 serves as an independent risk factor and a promising noninvasive predictor for IgAN progression.
- These findings highlight the potential of urinary IL-6 as a biomarker for monitoring IgAN.
Keywords:
IgA nephropathybiomarkerend-stage renal diseaseinterleukin-6progressiontransforming growth factor-beta 1More Related Videos
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