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Low-Frequency Repetitive Transcranial Magnetic Stimulation for Chronic Tension-Type Headache: A Randomized Controlled
Manju Rajain1, Renu Bhatia2, Manjari Tripathi3,2
1Department of Physiology, National Institute of Medical Sciences and Research, Jaipur, IND.
Cureus
|March 20, 2023
Summary
Repetitive transcranial magnetic stimulation (rTMS) effectively reduced pain and muscle activity in chronic tension-type headaches (CTTH). This therapy offers a promising new treatment option for CTTH patients.
Area of Science:
- Neurology
- Pain Management
- Neuroscience
Background:
- Chronic tension-type headaches (CTTH) affect 1-3% of the population, with unclear pathophysiology.
- Pericranial muscle overactivity and central pain modulation are implicated in CTTH.
- Repetitive transcranial magnetic stimulation (rTMS) may modulate these factors.
Purpose of the Study:
- To evaluate the efficacy of low-frequency rTMS targeting the dorsolateral prefrontal cortex (DLPFC) for CTTH.
- To assess the impact of rTMS on pain intensity and pericranial muscle activity in CTTH patients.
Main Methods:
- A randomized controlled study involving 20 CTTH subjects.
- Participants received either sham or low-frequency rTMS at the right DLPFC for two weeks.
- Statistical analysis was performed using Welch's corrected t-test.
Main Results:
- rTMS treatment significantly reduced pain intensity, pericranial muscle activity, and headache impact.
- Nociceptive excitability thresholds increased in the rTMS group compared to sham (p=0.001).
- Daily rTMS for two weeks demonstrated significant improvements.
Conclusions:
- Low-frequency rTMS is an effective treatment for reducing pain in CTTH.
- rTMS shows potential as a foundational therapy for further CTTH research.
