Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

223
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
223
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

12
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
12
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

11
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
11
Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

21
Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
21
Local Anesthetics: Adverse Effects01:12

Local Anesthetics: Adverse Effects

474
While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
474
Acid Suppressive Drugs for Peptic Ulcer Disease: Histamine H2-Receptor Antagonists01:28

Acid Suppressive Drugs for Peptic Ulcer Disease: Histamine H2-Receptor Antagonists

540
Histamine H2 receptors, which are intricately located on the basolateral membrane of parietal cells, play a crucial role in modulating gastric acid secretion. When released from enterochromaffin-like cells, histamine engages H2 receptors, initiating the cyclic AMP (cAMP) pathway. In this pathway, adenylyl cyclase converts ATP into cAMP, elevating intracellular cAMP levels. The activation of protein kinase A follows, stimulating the proton pump. This stimulation prompts the secretion of hydrogen...
540

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Skin care without borders: A United Kingdom-Myanmar teledermatology initiative.

The Journal of investigative dermatology·2026
Same author

Dietary Whole Wheat Flour Intake in Pakistan: A Cross-Sectional Insight into Long-Term Dementia Prevention.

Nutrients·2026
Same author

Potential Involvement of Fructosylated Human Insulin and Serological Evidence in Subclinical Autoimmune Activity in Type 2 Diabetes Mellitus.

Current diabetes reviews·2026
Same author

The Effectiveness of Home-Based Phototherapy in Vitiligo: A Systematic Review and Meta-Analysis.

Photodermatology, photoimmunology & photomedicine·2026
Same author

Excimer 308-Nm Light in the Combination Treatment of Vitiligo: A Systematic Review and Network Meta-Analysis.

Pigment cell & melanoma research·2026
Same author

Protective effect of crocin against glycated LDL-induced cytotoxicity and oxidative stress in isolated human erythrocytes.

Cytotechnology·2026
Same journal

A Retrospective Analysis of Cardiac Anatomy in Patients Undergoing the Fontan Operation.

Cureus·2026
Same journal

A Narrative Review of the Potential Impact of Next-Generation Tobacco and Nicotine Products on Cardiovascular Health.

Cureus·2026
Same journal

A Prospective Comparative Study for the Evaluation of Digital Learning as an Academic Tool for MBBS Phase III Students.

Cureus·2026
Same journal

Crossing the Septum: May-Thurner Syndrome and Patent Foramen Ovale as a Dual Mechanism for Recurrent Ischemic Stroke.

Cureus·2026
Same journal

Physical Restraint Practices, Attitudes, and Ethical Perceptions Among Intensive Care Unit (ICU) Doctors and Nurses in Morocco: A Cross-Sectional Survey Highlighting the Training-Use Paradox.

Cureus·2026
Same journal

Reversible Rapidly Progressive Dementia Due to Cerebral Amyloid Angiopathy.

Cureus·2026
See all related articles

Related Experiment Video

Updated: Aug 6, 2025

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin
07:38

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin

Published on: May 6, 2018

8.5K

Naproxen-Induced Evans Syndrome.

Ange Ahoussougbemey Mele1, Christopher Chew1, Ruben Ruiz Vega1

  • 1Internal Medicine, Northeast Georgia Medical Center, Gainesville, USA.

Cureus
|March 20, 2023
PubMed
Summary
This summary is machine-generated.

This case study identifies naproxen as a potential trigger for Evans syndrome, a rare autoimmune disorder. Early diagnosis and prompt treatment, including drug withdrawal, are crucial for managing this condition and improving patient outcomes.

Keywords:
autoimmune hemolytic anemia (aiha)evans’ syndromehematologyimmune thrombocytopenic purpuranaproxen

More Related Videos

An Optimized Evans Blue Protocol to Assess Vascular Leak in the Mouse
06:39

An Optimized Evans Blue Protocol to Assess Vascular Leak in the Mouse

Published on: September 12, 2018

26.9K
5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

23.7K

Related Experiment Videos

Last Updated: Aug 6, 2025

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin
07:38

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin

Published on: May 6, 2018

8.5K
An Optimized Evans Blue Protocol to Assess Vascular Leak in the Mouse
06:39

An Optimized Evans Blue Protocol to Assess Vascular Leak in the Mouse

Published on: September 12, 2018

26.9K
5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

23.7K

Area of Science:

  • Hematology
  • Immunology
  • Autoimmune Disorders

Background:

  • Evans syndrome is an autoimmune disorder involving autoimmune hemolytic anemia and immune thrombocytopenic purpura.
  • It can be primary (idiopathic) or secondary to other conditions.
  • Understanding triggers is vital for effective management and prevention of recurrence.

Observation:

  • A 68-year-old female presented with symptoms of Evans syndrome after naproxen use.
  • Workup revealed positive direct antiglobulin test (IgG), anemia, thrombocytopenia, and deep venous thrombosis.
  • The patient improved after treatment with corticosteroids, anticoagulants, blood transfusions, and naproxen discontinuation.

Findings:

  • This case is the first reported instance of naproxen-induced Evans syndrome.
  • Naproxen is identified as a potential trigger for primary Evans syndrome.
  • The patient demonstrated a positive response to standard treatment protocols.

Implications:

  • Highlights naproxen as a potential iatrogenic cause of Evans syndrome.
  • Emphasizes the importance of considering drug-induced causes in Evans syndrome diagnosis.
  • Suggests prompt discontinuation of offending agents alongside standard therapy for better prognosis.