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Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
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Association between systemic sclerosis and left ventricle dysfunction: Findings from observational studies.

Wei Yan1, Qiang Luo2, Qiong Nie1

  • 1Southwest Jiaotong University, Department of Geriatrics, Southwest Jiaotong University College of Medicine, The Third People's Hospital of Chengdu, No.82, Qinglong Street, Sichuan, China.

Heliyon
|March 20, 2023
PubMed
Summary
This summary is machine-generated.

Systemic sclerosis (SSc) patients commonly experience left ventricular dysfunction (LVD), including diastolic and systolic issues. Further research is needed to confirm the genetic link between SSc and LVD.

Keywords:
EchocardiographyKey messageLeft ventricular dysfunctionLeft ventricular ejection fractionMendelian randomizationMeta-analysisSystemic sclerosis

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Area of Science:

  • Cardiology
  • Rheumatology
  • Genetics

Background:

  • Cardiac involvement is a frequent complication in patients with systemic sclerosis (SSc).
  • Left ventricular dysfunction (LVD), particularly diastolic dysfunction, significantly impacts patient outcomes.

Purpose of the Study:

  • To systematically evaluate the association between SSc and LVD using ultrasound and cardiac magnetic resonance data.
  • To investigate potential causal relationships between SSc and LVD parameters via Mendelian randomization (MR).

Main Methods:

  • A meta-analysis of 31 studies involving 1448 SSc patients and controls was conducted.
  • Two-sample Mendelian randomization (MR) was performed using genome-wide association study (GWAS) summary statistics for LVD parameters.

Main Results:

  • SSc patients exhibited impaired diastolic function, indicated by altered E/A ratio, E', and increased E/E' ratio, IVRT, DT, and LA diameter.
  • Lower left ventricular ejection fraction (LVEF) was observed in SSc patients compared to controls.
  • MR analysis suggested a causal correlation between SSc and LVEF, but not with left ventricular mass (LVM) or left ventricular end-diastolic volume (LVEDV).

Conclusions:

  • Systemic sclerosis is associated with both diastolic and systolic left ventricular dysfunction.
  • Current MR analysis lacks sufficient data to confirm a genetic relationship between SSc and LVDD.
  • Further investigation is required to establish a definitive causal link between SSc and LVD.