Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Role of Hippocampus in Memory

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Review of Translational Behavioral Assays in Depression Research.

Biology·2026

Same author

Controlling Spatio-Temporal Sequences of Neural Activity by Local Synaptic Changes.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026

Same author

Competition and cooperation of assembly sequences in recurrent neural networks.

PLoS computational biology·2025

Same author

Perineuronal Nets on CA2 Pyramidal Cells and Parvalbumin-Expressing Cells Differentially Regulate Hippocampal-Dependent Memory.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2024

Same author

Investigating Resistance to Antidepressants in Animal Models.

Neuroscience·2024

Same author

Editorial: Molecular and network mechanisms underlying stress resilience.

Frontiers in molecular neuroscience·2024

Same journal

Opioid-Associated Hippocampal Injury: Past, Present, and Future Directions.

Hippocampus·2026

Same journal

Neural and Navigational Features Influencing the Novelty Induced Benefits on Episodic Memory.

Hippocampus·2026

Same journal

Intrinsic Persistent Firing in CA1 Encodes Elapsed Time Across Behaviorally Relevant Scales.

Hippocampus·2026

Same journal

Boundary Vector Cells Encode a Future-Biased Spectrum of Positions in the Rat.

Hippocampus·2026

Same journal

Hippocampal NOP Receptor Activation Impairs Object Recognition Memory Acquisition.

Hippocampus·2026

Same journal

Effects of Corticotropin-Releasing Factor 1 Receptor Antagonism on In Vivo Dentate Gyrus Long-Term Potentiation in the TgF344-AD Rat Model of Alzheimer's Disease.

Hippocampus·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Aug 6, 2025

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice

Published on: July 1, 2018

Silencing hippocampal CA2 reduces behavioral flexibility in spatial learning.

Andrew B Lehr¹, Frederick L Hitti^2,3, Scott H Deibel⁴

¹Department of Computational Synaptic Physiology, University of Göttingen, Göttingen, Germany.

|March 20, 2023

Summary

This summary is machine-generated.

Silencing the hippocampus region CA2 impairs spatial reversal learning. CA2-silenced mice struggled to adapt to a new platform location, showing perseverance and non-spatial strategies.

Keywords:

CA2 Morris water maze behavioral flexibility reversal learning spatial learning

More Related Videos

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

Published on: July 8, 2015

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Published on: May 12, 2015

Related Experiment Videos

Last Updated: Aug 6, 2025

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice

Published on: July 1, 2018

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

Published on: July 8, 2015

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Published on: May 12, 2015

Area of Science:

Neuroscience
Behavioral Neuroscience

Background:

The hippocampus is crucial for spatial learning and memory.
The specific role of hippocampal region CA2 in these processes is not well understood.

Purpose of the Study:

To investigate the involvement of hippocampal region CA2 in spatial reversal learning.
To determine if CA2 is necessary for adapting behavior when environmental contingencies change.

Main Methods:

Chronic silencing of dorsal CA2 in mice.
Behavioral assessment using the Morris water maze, including reversal learning tasks.
Analysis of spatial navigation strategies.

Main Results:

Mice with silenced CA2 showed impaired reversal learning after platform relocation.
These mice exhibited increased perseverance towards the old platform location.
CA2-silenced mice increasingly relied on non-spatial strategies during reversal learning.

Conclusions:

The dorsal CA2 region is recruited for flexible behavioral adaptation during spatial learning.
These findings highlight a direct role for CA2 in spatial learning and hippocampal information processing.
This study supports recent theories on CA2 function and suggests further research into its neural mechanisms.