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Hematological and biochemical profiles in children with cerebral palsy: A cross-sectional study
Rohit Khandelwal1, Vivek Vankalapati Manjunath1, Leeni Mehta2
1Department of Paediatrics, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, India.
Insights
Anemia and abnormal alkaline phosphatase levels are more common in children with cerebral palsy, particularly in younger males and females, respectively. These findings aid in improving patient care through timely interventions.
Area of Science:
- Pediatric Neurology
- Clinical Biochemistry
- Hematology
Background:
- Cerebral palsy (CP) is a prevalent pediatric neurological disorder often accompanied by nutritional challenges.
- Hematological and biochemical markers are crucial for assessing the health status of children with CP.
- Limited research has comprehensively analyzed these parameters in pediatric CP populations.
Purpose of the Study:
- To characterize the hematological and biochemical profiles of children diagnosed with cerebral palsy.
- To investigate the influence of age and gender on these parameters in pediatric CP.
Main Methods:
- A four-year observational study involving children with CP admitted to a pediatric department.
- Collected data on hemoglobin, platelet count, white blood cell (WBC) count, red blood cell (RBC) indices, and various biochemical markers.
- Performed age and gender-specific analyses to identify trends and significant differences.
Main Results:
- Average hemoglobin: 11.48 mg/dL; average platelet count: 301.24×10^9/L; average WBC count: 11.13×10^9/L.
- Anemia was more prevalent in males under nine years old. Low platelet counts (<150×10^9/L) were found in 4.96% of patients.
- Abnormal alkaline phosphatase levels were significantly more common in younger children (<9 years) and females compared to males.
Conclusions:
- Anemia disproportionately affects younger males with cerebral palsy.
- Bone turnover markers, such as alkaline phosphatase, show higher abnormality rates in young patients and females with CP.
- Understanding age and gender-specific parameter variations can guide timely interventions, enhancing the quality of life for children with CP.
Purpose:
Cerebral palsy is a common pediatric neurological problem that has multiple comorbidities, including nutritional issues. Hematological and biochemical parameters significantly affect the health status of patients with cerebral palsy, and till now very few studies have analyzed these parameters. This study aimed to describe the hematological and biochemical parameters of children diagnosed with cerebral palsy.
Methods:
This four-year observational study included children with cerebral palsy who were admitted to the Department of Pediatrics of a medical college teaching hospital.Hemoglobin, platelet count, white blood count (WBC), red blood cells (RBCs), packed cell volume, RBC indices, and biochemical parameters (urea, creatinine, total bilirubin, total protein, albumin, globulin, aspartate transaminase, alanine transaminase, electrolytes, calcium and alkaline phosphatase) were noted and values (mean, standard deviation, and interquartile range) presented. Age and gender-based analyses were performed.
Results:
The average hemoglobin level was 11.48 mg/dl, platelet count was 301.24×109/L, and WBC count was 11.13 109/L. Anemia was observed more commonly in males younger than nine years of age. Of 282 patients, 14 (4.96%) had a platelet count of less than 150×109/L. Abnormal alkaline phosphatase levels were observed more commonly in patients who were younger than nine years of age and in females more than males, and the difference was statistically significant. Protein levels and calcium levels were similar between both age groups.
Conclusion:
Anemia was more common in younger patients and males with cerebral palsy. Abnormal bone turnover markers (alkaline phosphatase) were more common in young patients and females with cerebral palsy. Understanding the differential effect of age and gender on various investigational parameters will help improve care of children with cerebral palsy by initiating appropriate and timely clinical interventions, thereby providing a better quality of life.
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