Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

49
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
49
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

30
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
30
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

35
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
35
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

41
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
41
Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

128
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
128
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

46
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
46

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Opioid Use and Pain Resolution for Acute Pain Among Opioid-Naive Patients.

JAMA network open·2026
Same author

Breast Cancer-related Lymphedema: A Comparative Ultrasound Study of Shear Wave Elastography and B-mode Measurements for Assessing Lymphaticovenous Anastomosis.

European journal of breast health·2026
Same author

Viral but Not Verified: Analyzing Accuracy and Engagement in TikTok Discussions of IUDs.

Healthcare (Basel, Switzerland)·2026
Same author

A monolithic patient-specific 3D-0D model for In silico investigation of hemodynamics in patients with left ventricular assist devices.

Biomechanics and modeling in mechanobiology·2026
Same author

LVV SMRTcap reveals extensive proviral variation in lentiviral vector-transduced CAR T cells.

bioRxiv : the preprint server for biology·2026
Same author

Endocrine therapy reprogramming of breast cancer facilitates metastatic escape via upregulation of P-Rex1/Rac1 signalling.

Nature communications·2026

Related Experiment Video

Updated: Aug 6, 2025

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

4.4K

A quality improvement intervention to decrease the decline in renal function in pediatric liver transplant

Irini Batsis1, Scott Elisofon2, Michael Ferguson3

  • 1Division of Hepatology, Mount Sinai Kravis Children's Hospital, New York, New York, USA.

Pediatric Transplantation
|March 20, 2023
PubMed
Summary
This summary is machine-generated.

Quality improvement initiatives significantly reduced chronic kidney disease in pediatric liver transplant recipients. Enhanced monitoring and management plans decreased the prevalence of low estimated glomerular filtration rate (eGFR) at 12 and 24 months post-transplant.

Keywords:
chronic kidney diseaseeGFRimmunosuppressionpediatric liver transplantationquality improvement

More Related Videos

Robot-Assisted Kidney Transplantation
07:30

Robot-Assisted Kidney Transplantation

Published on: July 19, 2021

3.7K
Murine Renal Transplantation Procedure
18:48

Murine Renal Transplantation Procedure

Published on: July 10, 2009

29.9K

Related Experiment Videos

Last Updated: Aug 6, 2025

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

4.4K
Robot-Assisted Kidney Transplantation
07:30

Robot-Assisted Kidney Transplantation

Published on: July 19, 2021

3.7K
Murine Renal Transplantation Procedure
18:48

Murine Renal Transplantation Procedure

Published on: July 10, 2009

29.9K

Area of Science:

  • Pediatric Nephrology
  • Transplant Medicine
  • Quality Improvement Science

Background:

  • Chronic kidney disease (CKD) is a significant long-term complication in pediatric liver transplant (LT) recipients.
  • Prevalence of estimated glomerular filtration rate (eGFR) < 90 mL/min/1.73 m² was 25% at 1 year post-LT, necessitating intervention.
  • A quality improvement (QI) project aimed to reduce the incidence of eGFR < 90 by at least 20% within 1 year post-LT.

Purpose of the Study:

  • To implement and evaluate the effectiveness of QI interventions to decrease the prevalence of CKD in pediatric LT recipients.
  • To improve the documentation of key renal parameters and management strategies post-LT.
  • To assess the impact of interventions on eGFR levels at 3, 12, and 24 months post-LT.

Main Methods:

  • A QI project involving three interventions was implemented starting January 2016 for pediatric patients (<19 years) undergoing LT between 2010-2018.
  • Interventions included standardized documentation of blood pressure percentile (BP%) and eGFR, creation of kidney management plans for abnormal values, and pre-discharge amlodipine initiation.
  • Pre- and post-intervention cohorts were compared for the prevalence of eGFR < 90 at 3, 12, and 24 months post-LT.

Main Results:

  • Post-intervention, documentation rates for BP%, eGFR, and kidney management plans significantly increased from 25%, 10%, 22% to 71%, 83%, 71% respectively.
  • Amlodipine initiation prior to discharge rose from 22% to 74% post-intervention.
  • The prevalence of eGFR < 90 at 12 months post-LT decreased significantly from 24% to 7% (p=0.01), representing a 74% relative reduction.

Conclusions:

  • QI interventions, including improved documentation and proactive management, effectively reduced the prevalence of CKD in pediatric LT recipients.
  • A significant decrease in the prevalence of eGFR < 90 was observed at 12 months post-LT, exceeding the project's goal.
  • Malignancy, metabolic disorders, and older age at transplant were identified as significant non-modifiable risk factors for reduced eGFR.