Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association between intra- and peritumoral heterogeneity on B-mode ultrasound and overall survival in patients with liver metastases treated with immunotherapy.

European radiology experimental·2026
Same author

Role of ctDNA Tumor Fraction in Selecting Immunotherapy Based Regimens in Advanced Non-small Cell Lung Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

A plasma proteomic signature of cancer-related sarcopenia implicates the IGFBP axis in muscle dysfunction.

Molecular cancer·2026
Same author

Deep Learning Predicts Mutations and Outcomes in Gastrointestinal Stromal Tumors from Whole-Slide Images.

Cancer research·2026
Same author

Predicting survival of patients treated with antibody-drug conjugates in early-phase clinical trials using AI-quantified 3D body composition on CT scans.

Frontiers in oncology·2026
Same author

Integrating tumor volumetry and liquid biopsy: a New model to define prognosis in advanced pancreatic ductal adenocarcinoma.

European journal of cancer (Oxford, England : 1990)·2026

Related Experiment Video

Updated: Aug 6, 2025

An Experimental Protocol for Assessing the Performance of New Ultrasound Probes Based on CMUT Technology in Application to Brain Imaging
16:01

An Experimental Protocol for Assessing the Performance of New Ultrasound Probes Based on CMUT Technology in Application to Brain Imaging

Published on: September 24, 2017

10.5K

New calibration setup for quantitative DCE-US imaging protocol: Toward standardization.

Isaline Hoferer1,2, Laurene Jourdain1, Charly Girot1

  • 1Université Paris-Saclay, CEA, CNRS, Inserm, BioMaps, Gustave Roussy Cancer Campus, Villejuif, France.

Medical Physics
|March 20, 2023
PubMed
Summary

A new calibration setup allows Dynamic Contrast-Enhanced Ultrasonography (DCE-US) imaging protocols to be standardized across different ultrasound scanner generations. This ensures reliable quantitative imaging for monitoring cancer treatments.

Keywords:
Dynamic contrast-enhanced ultrasound (DCE-US)Methodologies of ultrasound calibrationUltrasound contrast agentphantom

More Related Videos

Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants
11:39

Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants

Published on: March 14, 2013

20.5K
Author Spotlight: Enhanced Quantification of Cardiovascular Calcification Progression for Longitudinal Micro PET/CT Studies in Small Research Animals
08:02

Author Spotlight: Enhanced Quantification of Cardiovascular Calcification Progression for Longitudinal Micro PET/CT Studies in Small Research Animals

Published on: November 15, 2024

663

Related Experiment Videos

Last Updated: Aug 6, 2025

An Experimental Protocol for Assessing the Performance of New Ultrasound Probes Based on CMUT Technology in Application to Brain Imaging
16:01

An Experimental Protocol for Assessing the Performance of New Ultrasound Probes Based on CMUT Technology in Application to Brain Imaging

Published on: September 24, 2017

10.5K
Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants
11:39

Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants

Published on: March 14, 2013

20.5K
Author Spotlight: Enhanced Quantification of Cardiovascular Calcification Progression for Longitudinal Micro PET/CT Studies in Small Research Animals
08:02

Author Spotlight: Enhanced Quantification of Cardiovascular Calcification Progression for Longitudinal Micro PET/CT Studies in Small Research Animals

Published on: November 15, 2024

663

Area of Science:

  • Medical Imaging
  • Ultrasound Technology
  • Quantitative Biomarkers

Background:

  • Dynamic Contrast-Enhanced Ultrasonography (DCE-US) offers quantitative biomarkers for monitoring anti-angiogenic cancer treatments, complementing morphological assessments.
  • Standardization issues arise when applying DCE-US protocols across different ultrasound scanner generations, probes, and settings.
  • Existing methods primarily rely on morphological changes, necessitating quantitative imaging for consistent patient follow-up.

Purpose of the Study:

  • To develop a novel, reproducible, and cost-effective calibration setup for transposing DCE-US imaging protocols to newer ultrasound scanner generations.
  • To validate the calibration method using both abdominal and linear probes.

Main Methods:

  • A concentration splitter was employed to generate four simultaneous contrast agent concentrations (12.5% to 100%) for measuring harmonic signal intensity variations.
  • The Area Under the time-intensity Curve (AUC) was calculated for each concentration to determine the slope, serving as the calibration parameter.
  • Two ultrasound scanners (Aplio500 and Aplioi900) were calibrated by adjusting Mechanical Index (MI) and Color Gain (CG) settings to achieve matching slopes.

Main Results:

  • The calibration setup demonstrated excellent measurement repeatability (96.8%).
  • Post-calibration, excellent reproducibility was achieved, with quantitative measurement agreement between scanners ranging from 95.4% to 98.8%.
  • Validated settings for the Aplioi900 were determined: Abdominal probe (MI=0.13, CG=34 dB) and Linear probe (MI=0.10, CG=38 dB).

Conclusions:

  • The developed calibration setup provides reliable measurements for quantitative imaging.
  • It facilitates the rapid transfer and consistent application of DCE-US protocols to new ultrasound scanners.
  • This enables uninterrupted therapeutic evaluation of patients undergoing anti-angiogenic treatments.