Related Experiment Video
Updated: Aug 6, 2025

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
Published on: April 23, 2019
Outpatient Opioid Dispensing Patterns for SC Medicaid Children 1-36 Months Old
Laksika Banu M Sivaraj1, William T Basco2, Smith F Heavner1,3,4
1Department of Public Health Sciences, Clemson University, Clemson, SC, USA.
Insights
Pediatric opioid prescriptions declined for respiratory, injury, nervous system, and digestive conditions in children aged 1-36 months. However, congenital anomalies and genitourinary conditions saw increased opioid use.
Area of Science:
- Pediatric pharmacology
- Public health
- Epidemiology
Background:
- Opioid prescriptions in young children (1-36 months) are a public health concern.
- Understanding diagnostic patterns associated with pediatric opioid use is crucial for targeted interventions.
Purpose of the Study:
- To identify common diagnostic categories for opioid prescriptions in young children.
- To analyze trends in these diagnostic categories from 2000 to 2017.
Main Methods:
- Utilized South Carolina Medicaid claims data for pediatric outpatient opioid prescriptions (2000-2017).
- Identified major opioid-related diagnostic categories using primary visit diagnoses and the Clinical Classification System (AHRQ-CCS).
- Analyzed rates per 1,000 visits and relative percentages for each diagnostic category.
Main Results:
- Six major categories identified: Respiratory (RESP), Congenital anomalies (CONG), Injury (INJURY), Nervous system (NEURO), Digestive (GI), and Genitourinary (GU).
- Opioid prescription rates declined for RESP, INJURY, NEURO, and GI categories.
- Rates increased for CONG and GU categories, with CONG becoming the most prevalent by 2014.
Conclusions:
- Opioid dispensing rates decreased for most major diagnostic categories in young Medicaid beneficiaries.
- Further research is needed to explore alternative pain management strategies for congenital anomalies and genitourinary conditions in children.
Objectives:
We sought to identify the most common diagnostic categories linked to dispensed opioid prescriptions among children 1-36 months old and changes in patterns over the years 2000 to 2017.
Methods:
This study used South Carolina's Medicaid claims data of pediatric dispensed outpatient opioid prescriptions between 2000 and 2017. The major opioid-related diagnostic category (indication) for each prescription was identified using visit primary diagnoses and the Clinical Classification System (AHRQ-CCS) software. The variables of interest were the rate of opioid prescriptions per 1,000 visits for each diagnostic category and the relative percentage of opioid prescriptions assigned to each category compared to all categories.
Results:
Six major diagnostic categories were identified; Diseases of the respiratory system (RESP), Congenital anomalies (CONG), Injury (INJURY), Diseases of the nervous system and sense organs (NEURO), Diseases of the digestive system (GI), and Diseases of the genitourinary system (GU). The overall rate of dispensed opioid prescriptions per category declined significantly for four diagnostic categories throughout the study period, RESP by 15.13, INJURY by 8.49, NEURO by 7.33, and GI by 5.93. Two categories increased during the same time, CONG (by 9.47) and GU (by 6.98). RESP was the most prevalent category linked to a dispensed opioid prescription within 2010-2012 (almost 25%) but CONG was the most prevalent by 2014 (17.77%).
Conclusions For Practice:
Among Medicaid children 1-36 months old, annual dispensed opioid prescription rates declined for most major diagnostic categories (RESP, INJURY, NEURO, and GI). Future studies should explore alternatives to current opioid dispensing practices for GU and CONG cases.
Related Concept Videos
Opioid Analgesics: Synthetic and Semisynthetic Opioids
Prescription, Nonprescription and Orphan Drugs
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
Opioid Analgesics: Morphine and Other Natural Cogeners
Drug Dosage Regimen: Overview
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...
Factors Affecting Drug Response: Overview

