Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mutation, Gene Flow, and Genetic Drift01:09

Mutation, Gene Flow, and Genetic Drift

58.9K
In a population that is not at Hardy-Weinberg equilibrium, the frequency of alleles changes over time. Therefore, any deviations from the five conditions of Hardy-Weinberg equilibrium can alter the genetic variation of a given population. Conditions that change the genetic variability of a population include mutations, natural selection, non-random mating, gene flow, and genetic drift (small population size).
58.9K
Genetic Drift03:33

Genetic Drift

40.2K
Natural selection—probably the most well-known evolutionary mechanism—increases the prevalence of traits that enhance survival and reproduction. However, evolution does not merely propagate favorable traits, nor does it always benefit populations.
40.2K
Factors Affecting Activity Coefficient01:17

Factors Affecting Activity Coefficient

854
The extended Debye-Hückel equation indicates that the activity coefficient of an ion in an aqueous solution at 25°C depends on three partially interdependent properties: the ionic strength of the solution, the charge of the ion, and the ion size. 
The activity coefficient value for an ion is close to one when the solution has almost zero ionic strength, i.e., when the solution shows close to ideal behavior. As the ionic strength of the solution increases from 0 to 0.1 mol/L, a...
854
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

15.4K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
15.4K
Drug Concentration Versus Time Correlation01:15

Drug Concentration Versus Time Correlation

957
The plasma drug concentration-time curve is a crucial tool in pharmacokinetics, representing the drug's concentration in plasma at different time intervals post-administration. This curve illustrates the drug's journey from absorption into the systemic circulation, distribution to body tissues, and eventual elimination through excretion or biotransformation.
Two pivotal parameters are the minimum effective concentration (MEC) and the minimum toxic concentration (MTC). The MEC is the...
957
Regression Toward the Mean01:52

Regression Toward the Mean

6.3K
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
6.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Discovery of a Novel Lung-Restricted ALK5 Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis.

Journal of medicinal chemistry·2026
Same author

Data Fusion Combining High-Resolution Mass Spectrometry and <sup>1</sup>H-NMR Metabolomic Data with Gluten Protein Content to Assess the Impact of Agro-Sustainable Treatments on Durum Wheat.

Molecules (Basel, Switzerland)·2026
Same author

Untargeted approaches based on GC-Orbitrap-HRMS and two-dimensional GC-MS for the identification of intentionally and non-intentionally added substances from bio-based food contact materials.

Analytical and bioanalytical chemistry·2026
Same author

Nodal Heterogeneity can Induce Ghost Triadic Effects in Relational Event Models.

Psychometrika·2026
Same author

Dyspnoea patterns in patients with advanced diseases: a functional MRI feasibility study protocol.

BMJ open·2026
Same author

Tongue Strength and Endurance in Patients with Parkinson's Disease: Association with Swallowing, Oral Phase Efficiency, Meal, Diet Type and Malnutrition Risk.

Dysphagia·2025
Same journal

Analysis of strength degradation of coal and rock masses and stability of mined areas under long term immersion environment.

PloS one·2026
Same journal

Biogenic Silver-Selenium nanocomposite with anticancer activity and potent efficacy against vancomycin-resistant Staphylococcus aureus.

PloS one·2026
Same journal

Preparation and physicochemical characterization of a biodegradable chitosan/carboxymethyl cellulose hydrogel synthesized in NaOH/urea medium.

PloS one·2026
Same journal

Action-guilt, survivor-guilt, and depression in combat-related PTSD.

PloS one·2026
Same journal

Explainable machine learning for predicting activities of daily living at discharge in stroke patients: A retrospective study using SHAP interpretability.

PloS one·2026
Same journal

Deep learning based two-way feature depiction model for brain tumor detection.

PloS one·2026
See all related articles

Related Experiment Video

Updated: Aug 6, 2025

Author Spotlight: Addressing Regulatory Gaps in Molecular Studies by Quantifying Viral Vectors in Complex Matrices
07:43

Author Spotlight: Addressing Regulatory Gaps in Molecular Studies by Quantifying Viral Vectors in Complex Matrices

Published on: July 14, 2023

2.1K

Drivers of the decrease of patent similarities from 1976 to 2021.

Edoardo Filippi-Mazzola1, Federica Bianchi1, Ernst C Wit1

  • 1Institute of Computing, Università della Svizzera italiana, Lugano, Switzerland.

Plos One
|March 20, 2023
PubMed
Summary
This summary is machine-generated.

Patent analysis reveals a decrease in textual similarity over time. Advanced Natural Language Processing and generalized additive models uncover new drivers of this trend, offering a more nuanced understanding of patent evolution.

More Related Videos

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings
19:57

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings

Published on: March 30, 2014

18.6K
Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
10:44

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

Published on: December 7, 2021

2.2K

Related Experiment Videos

Last Updated: Aug 6, 2025

Author Spotlight: Addressing Regulatory Gaps in Molecular Studies by Quantifying Viral Vectors in Complex Matrices
07:43

Author Spotlight: Addressing Regulatory Gaps in Molecular Studies by Quantifying Viral Vectors in Complex Matrices

Published on: July 14, 2023

2.1K
An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings
19:57

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings

Published on: March 30, 2014

18.6K
Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
10:44

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

Published on: December 7, 2021

2.2K

Area of Science:

  • Intellectual Property Analysis
  • Bibliometrics
  • Natural Language Processing (NLP)

Background:

  • Patent citation networks reflect legal disclosure obligations.
  • Textual similarity analysis is a method to study patent relationships.
  • Existing patent similarity indicators show a declining trend since the mid-1970s.

Purpose of the Study:

  • To investigate potential drivers of the observed decrease in patent textual similarity.
  • To apply computationally efficient NLP tools for patent similarity scoring.
  • To model patent similarity using generalized additive models.

Main Methods:

  • Development of a computationally efficient patent similarity measure using state-of-the-art Natural Language Processing (NLP).
  • Application of generalized additive models (GAMs) to model patent similarity scores.
  • Analysis of temporally varying drivers influencing patent similarity levels.

Main Results:

  • Non-linear modeling specifications successfully identified distinct, time-varying drivers of patent similarity.
  • The proposed models explain a significant portion of the variation in similarity data (R² ≈ 18%), outperforming previous methods.
  • The study reveals an underlying trend in patent similarity scores that differs from previously reported findings.

Conclusions:

  • Advanced NLP and generalized additive models provide a more comprehensive understanding of patent similarity dynamics.
  • The identified drivers and underlying trends offer a revised perspective on the evolution of patent textual similarity.
  • This approach enhances the analysis of patent relationships and technological evolution.