Related Experiment Video
Updated: Aug 6, 2025
13:34
Assessment of Memory Function in Pilocarpine-induced Epileptic Mice
Published on: June 4, 2020
8.4K
The relationship between physical activity and cognitive function in people with epilepsy: A systematic review
Halley B Alexander1, Jane B Allendorfer2
1Wake Forest University School of Medicine, Department of Neurology, Winston-Salem, NC, USA.
Epilepsy & Behavior : E&B
|March 20, 2023
Summary
Physical activity may improve cognitive function in people with epilepsy (PWE). However, current research is limited, necessitating larger, more robust studies to confirm this association.
Area of Science:
- Neurology
- Exercise Science
- Cognitive Neuroscience
Background:
- Epilepsy is a chronic neurological disorder affecting millions worldwide.
- Cognitive dysfunction is a common comorbidity in people with epilepsy (PWE).
- The role of physical activity in mitigating cognitive decline in PWE remains underexplored.
Approach:
- Systematic review of published literature on physical activity and cognitive function in PWE.
- Searched major databases (PubMed, Cochrane, Embase, PsychInfo) up to June 20, 2022.
- Included observational and interventional studies adhering to PRISMA guidelines, assessed with GRADE scale.
Key Points:
- Six studies with 123 participants were analyzed.
- A positive association was observed between physical activity and cognitive function in PWE.
- Interventional studies demonstrated cognitive improvements, despite outcome measure heterogeneity.
Conclusions:
- A potential link exists between physical activity and enhanced cognitive function in PWE.
- Current evidence is limited by small sample sizes and study heterogeneity.
- Further high-quality research with larger cohorts is crucial to validate these findings.
Related Concept Videos
01:24Epilepsy and Seizures: Overview
235
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
235
01:13Seizures: Classification
492
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
492
01:20Antiepileptic Drugs: Potassium Channel Activators
233
Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
Ezogabine has gained approval as an adjunctive treatment...
233