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Updated: Aug 6, 2025
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Veno-Venous Extracorporeal Membrane Oxygenation in a Mouse
Published on: October 24, 2018
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Extracorporeal Membrane Oxygenation in Intoxication and Overdoses: A Systematic Review
Sven Maier1,2, Lisa Rösner1,2, Lars Saemann3
1Department of Cardiovascular Surgery, Medical Center-University of Freiburg, Freiburg, Baden-Württemberg, Germany.
The Thoracic and Cardiovascular Surgeon
|March 20, 2023
Summary
Extracorporeal membrane oxygenation (ECMO) is effective for severe poisoning cases. This review found high survival rates for patients treated with ECMO for intoxication and cardiac arrest.
Area of Science:
- Critical Care Medicine
- Toxicology
- Cardiovascular Medicine
Background:
- Acute intoxication can lead to severe cardiogenic shock or cardiac arrest.
- Extracorporeal membrane oxygenation (ECMO) is increasingly used for critical conditions like lung failure and cardiac arrest.
Approach:
- A qualitative systematic review was conducted.
- Searched PubMed, Medline, and Web of Science databases (1971-2021).
- Analyzed 145 articles involving 539 patients treated for intoxication.
Key Points:
- ECMO use in intoxication and poisoning was systematically evaluated.
- Included venovenous (vv) ECMO, venoarterial (va) ECMO, and extracorporeal cardiopulmonary resuscitation (ECPR).
- Overall survival at hospital discharge was 61.0%.
Conclusions:
- ECMO demonstrates a high survival rate for both adult and pediatric patients with intoxication.
- vaECMO showed 68.8% survival, vvECMO 75%, and ECPR 50.9%.
- ECMO is a valid therapeutic option for managing severe poisoning cases.
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