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An Update of Pharmacological Management in Children with Functional Constipation

Anna de Geus1, Ilan J N Koppen1, Robert B Flint2,3

  • 1Department of Pediatric Gastroenterology and Nutrition, Emma Children's Hospital/Academic Medical Center, Meibergdreef 9, 1105, Amsterdam, AZ, The Netherlands.

Paediatric Drugs
|March 21, 2023
PubMed

Insights

This review updates on pediatric functional constipation pharmacologic treatments. Polyethylene glycol is a first-line option, with other laxatives and emerging drugs available, though more research is needed.

Area of Science:

  • Pediatric Gastroenterology
  • Pharmacology

Background:

  • Functional constipation is a prevalent childhood disorder impacting children and families.
  • Diagnosis relies on Rome IV criteria, with initial management focusing on non-pharmacological approaches.

Purpose of the Study:

  • To review current literature on pharmacologic treatments for functional constipation in children.
  • To provide an update on established and emerging therapeutic options.

Main Methods:

  • Literature review of pharmacologic treatments for pediatric functional constipation.
  • Analysis of treatment strategies including disimpaction, maintenance, and weaning.

Main Results:

  • Polyethylene glycol is the primary choice for disimpaction and maintenance therapy.
  • Various alternative laxatives, lubricants, and enemas exist.
  • Novel drugs show promise but require more high-quality pediatric research.

Conclusions:

  • Pharmacologic management of pediatric functional constipation involves stepwise approaches.
  • Polyethylene glycol remains a cornerstone treatment.
  • Further research is essential for novel pharmacologic agents and invasive options like botulinum toxin injections.

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