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Updated: Aug 6, 2025

Experimental Model to Evaluate Resolution of Pneumonia
Published on: February 17, 2023
Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance
Gaetano Scaramuzzo1,2, Francesco Nucera3, Alessio Asmundo4
1Department of Translational Medicine, University of Ferrara, Ferrara, Italy.
Abstract:
The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection can be asymptomatic or cause a disease (COVID-19) characterized by different levels of severity. The main cause of severe COVID-19 and death is represented by acute (or acute on chronic) respiratory failure and acute respiratory distress syndrome (ARDS), often requiring hospital admission and ventilator support.The molecular pathogenesis of COVID-19-related ARDS (by now termed c-ARDS) is still poorly understood. In this review we will discuss the genetic susceptibility to COVID-19, the pathogenesis and the local and systemic biomarkers correlated with c-ARDS and the therapeutic options that target the cell signalling pathways of c-ARDS.
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